Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967163537> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1967163537 endingPage "849" @default.
- W1967163537 startingPage "842" @default.
- W1967163537 abstract "Thyroid iodide labeled 72 h earlier with 131I was separated from organic iodine by polyacrylamide gel electrophoresis. The concentration of thyroid radioiodide was not significantly diminished 2 h after the administration of perchlorate (100 mg NaClO4) alone, but perchlorate reduced the rise in glandular radioiodide caused by simultaneously given TSH (1 IU). When propylthiouracil (PTU; 20 mg) was given along with it, perchlorate decreased thyroid radioiodide even in rats not treated with TSH. In rats given perchlorate, PTU caused a much slighter augmentation of the TSH-induced increase in the thyroid radioiodide concentration than in the absence of perchlorate. These results are interpreted as follows. Perchlorate-discharged iodide in rats not given TSH is largely transported iodide. Perchlorate can discharge intrathyroidally generated (internal) iodide too, but this is unequivocally reflected by a decrease in the thyroid iodide concentration only when the production of internal iodide is enhanced by TSH. Perchlorate in its own right interferes with organic binding of internal iodide, thereby partially preempting the effect whereby PTU causes accumulation of internal iodide in TSH-treated rats. We suggest that internal thyroid iodide is transported from its site of generation, the follicular cell, to its site of organic binding, the follicular lumen, by perchlorate-sensitive transport. It is also possible that internal iodide escaping from a follicle is conserved by perchlorate-inhibitable reuptake into follicular cells closer to the venous end of the capillary bed. (Endocrinology108: 842, 1981)" @default.
- W1967163537 created "2016-06-24" @default.
- W1967163537 creator A5016349921 @default.
- W1967163537 creator A5033234998 @default.
- W1967163537 date "1981-03-01" @default.
- W1967163537 modified "2023-10-14" @default.
- W1967163537 title "Intrathyroidally Generated Iodide: The Role of Transport in Its Utilization*" @default.
- W1967163537 cites W1557766232 @default.
- W1967163537 cites W1559209231 @default.
- W1967163537 cites W1967825691 @default.
- W1967163537 cites W1972587258 @default.
- W1967163537 cites W1975978369 @default.
- W1967163537 cites W1985633291 @default.
- W1967163537 cites W1996499441 @default.
- W1967163537 cites W2014654034 @default.
- W1967163537 cites W2021490203 @default.
- W1967163537 cites W2022649448 @default.
- W1967163537 cites W2023918428 @default.
- W1967163537 cites W2027779138 @default.
- W1967163537 cites W2052869337 @default.
- W1967163537 cites W2052875054 @default.
- W1967163537 cites W2061959977 @default.
- W1967163537 cites W2062508458 @default.
- W1967163537 cites W2079703912 @default.
- W1967163537 cites W2084683287 @default.
- W1967163537 cites W2100283715 @default.
- W1967163537 cites W2115033425 @default.
- W1967163537 cites W2142599674 @default.
- W1967163537 cites W2179389126 @default.
- W1967163537 cites W2254975960 @default.
- W1967163537 cites W2335591018 @default.
- W1967163537 cites W2339895659 @default.
- W1967163537 cites W2396434645 @default.
- W1967163537 cites W3015302834 @default.
- W1967163537 cites W48761538 @default.
- W1967163537 cites W54282894 @default.
- W1967163537 doi "https://doi.org/10.1210/endo-108-3-842" @default.
- W1967163537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7460845" @default.
- W1967163537 hasPublicationYear "1981" @default.
- W1967163537 type Work @default.
- W1967163537 sameAs 1967163537 @default.
- W1967163537 citedByCount "18" @default.
- W1967163537 countsByYear W19671635372013 @default.
- W1967163537 countsByYear W19671635372018 @default.
- W1967163537 crossrefType "journal-article" @default.
- W1967163537 hasAuthorship W1967163537A5016349921 @default.
- W1967163537 hasAuthorship W1967163537A5033234998 @default.
- W1967163537 hasConcept C126322002 @default.
- W1967163537 hasConcept C134018914 @default.
- W1967163537 hasConcept C145148216 @default.
- W1967163537 hasConcept C178790620 @default.
- W1967163537 hasConcept C179104552 @default.
- W1967163537 hasConcept C185592680 @default.
- W1967163537 hasConcept C2775960720 @default.
- W1967163537 hasConcept C2776254400 @default.
- W1967163537 hasConcept C2778057883 @default.
- W1967163537 hasConcept C2778870691 @default.
- W1967163537 hasConcept C2779123554 @default.
- W1967163537 hasConcept C2780709120 @default.
- W1967163537 hasConcept C526584372 @default.
- W1967163537 hasConcept C539932907 @default.
- W1967163537 hasConcept C71924100 @default.
- W1967163537 hasConceptScore W1967163537C126322002 @default.
- W1967163537 hasConceptScore W1967163537C134018914 @default.
- W1967163537 hasConceptScore W1967163537C145148216 @default.
- W1967163537 hasConceptScore W1967163537C178790620 @default.
- W1967163537 hasConceptScore W1967163537C179104552 @default.
- W1967163537 hasConceptScore W1967163537C185592680 @default.
- W1967163537 hasConceptScore W1967163537C2775960720 @default.
- W1967163537 hasConceptScore W1967163537C2776254400 @default.
- W1967163537 hasConceptScore W1967163537C2778057883 @default.
- W1967163537 hasConceptScore W1967163537C2778870691 @default.
- W1967163537 hasConceptScore W1967163537C2779123554 @default.
- W1967163537 hasConceptScore W1967163537C2780709120 @default.
- W1967163537 hasConceptScore W1967163537C526584372 @default.
- W1967163537 hasConceptScore W1967163537C539932907 @default.
- W1967163537 hasConceptScore W1967163537C71924100 @default.
- W1967163537 hasIssue "3" @default.
- W1967163537 hasLocation W19671635371 @default.
- W1967163537 hasLocation W19671635372 @default.
- W1967163537 hasOpenAccess W1967163537 @default.
- W1967163537 hasPrimaryLocation W19671635371 @default.
- W1967163537 hasRelatedWork W1967163537 @default.
- W1967163537 hasRelatedWork W1979693058 @default.
- W1967163537 hasRelatedWork W1999719316 @default.
- W1967163537 hasRelatedWork W2014654034 @default.
- W1967163537 hasRelatedWork W2029657228 @default.
- W1967163537 hasRelatedWork W2032301001 @default.
- W1967163537 hasRelatedWork W2042065734 @default.
- W1967163537 hasRelatedWork W2057103028 @default.
- W1967163537 hasRelatedWork W2092351636 @default.
- W1967163537 hasRelatedWork W2161008999 @default.
- W1967163537 hasVolume "108" @default.
- W1967163537 isParatext "false" @default.
- W1967163537 isRetracted "false" @default.
- W1967163537 magId "1967163537" @default.
- W1967163537 workType "article" @default.