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- W1967164090 abstract "Heart metabolism is predominantly aerobic, through fat oxidation. During ischemia, glycolytic metabolism is stimulated and contributes significantly to cardiac energy supply. Chronic training upregulates fat utilization and therefore contribute to cell survival during left ventricular (LV) remodeling post acute myocardial infarction (AMI). Purpose: To study the effect of exercise training prior to AMI on the activity of key enzymes involved in heart energy metabolism during LV remodeling. Methods: Rats (n=28) underwent 3 weeks of swimming exercise training (Ex), or remained sedentary (Sed). Following the Ex/Sed period, all rats were subjected to AMI and thereafter remained sedentary for 4 weeks until sacrificed. Echocardiography was performed: at the end of the Ex/Sed period, 24 h following AMI, and 4 weeks after AMI. At sacrifice, hearts were harvested and assayed for enzyme activities using standard spectrophotometric and isotope techniques. Results: Higher shortening fractions was measured in prior Ex AMI rats compared with Sed AMI rats at 24 h-post-AMI and 4 weeks post AMI (p<0.05). Although hexokinase activity was not significant in the Ex group (p=0.09), the activities of the remaining enzymes were significantly higher in prior Ex AMI group: glycogen phosphorylase (63±6 vs. 40±5 μmol/g dw/min; p<0.03), citrate synthase (305±22 vs. 216±26 μmol/g dw/min; p<0.03), and 3-Hydroxyacyl-CoA dehydrogenase (171±26 vs. 79±8 μmol/g dw/min; p<0.02)." @default.
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- W1967164090 date "2007-06-01" @default.
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- W1967164090 title "Exercise prior to myocardial infarction improves cardiac healing through alterations in heart energy metabolism" @default.
- W1967164090 doi "https://doi.org/10.1016/j.yjmcc.2007.03.793" @default.
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