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• W1967182533 abstract "The uptake of catecholamines into rat brain synaptosomes was studied without suppressing MAO activity. Control experiments confirmed that in our purified synaptosomal preparations catecholamine metabolism was attributable to intrasynaptosomal MAO activity only. Thus, total uptake was defined as the sum of accumulated and metabolised amine. The following results were found. (1) Accumulation of dopamine (DA) as well as norepinephrine (NE) reached a saturation level after about 20 min. Deaminated products were formed in a linear fashion over time. However, NE metabolites constituted less than 20% of the total NE taken up at 20 min, while DA metabolites were an important part of the total DA taken up (44 and 77% at 2 and 20 min, respectively). (2) The distribution of deaminated metabolites between the intrasynaptosomal compartment and the incubation medium was consistent with the assumption that they were released from the synaptosomes by passive diffusion. (3) Kinetic investigations of active transport gave Km values of 1 × 10−7 M for DA uptake and 5 × 10−7 M for NE uptake. For DA, but not for NE, results for maximal velocities were considerably higher when calculated on the basis of the sum of accumulation and metabolism, compared to accumulation alone. (4) Blocking MAO activity resulted in a reduced total DA uptake to approximately the same level of accumulation as in controls. Total NE uptake was not significantly affected by MAO inhibition. (5) In synaptosomes from reserpinized animals, a significant decrease of accumulation of both DA and NE was found. In the case of DA this reduction was largely compensated by increased MAO activity, while with NE the decrease of storage resulted in a lower total uptake of NE. It is concluded from these results that intrasynaptosomal MAO activity allows removal of DA from the extracellular space under conditions in which equilibrium between inward and outward fluxes would otherwise abolish net uptake of DA. With NE, however, MAO activity was too low to accomplish this function, and the fate of this amine subsequent to its uptake seems to depend mainly on intracellular storage." @default.
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• W1967182533 date "1981-10-01" @default.
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• W1967182533 title "Uptake and metabolism of catecholamines in rat brain synaptosomes: Studies on the contribution of monoamine oxidase" @default.
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• W1967182533 doi "https://doi.org/10.1016/0006-2952(81)90415-9" @default.
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