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• W1967188390 endingPage "557" @default.
• W1967188390 startingPage "547" @default.
• W1967188390 abstract "Inherent properties of materials, such as their adhesiveness to cells, nanotopography, stiffness, degradability or chemical functionality, can influence the fate of stem cells. This Review discusses recent evidence of how inherent material properties can be engineered to regulate stem cell decisions, as well as of signal-transduction mechanisms that convert material stimuli into biochemical signals. The stem cell/material interface is a complex, dynamic microenvironment in which the cell and the material cooperatively dictate one another's fate: the cell by remodelling its surroundings, and the material through its inherent properties (such as adhesivity, stiffness, nanostructure or degradability). Stem cells in contact with materials are able to sense their properties, integrate cues via signal propagation and ultimately translate parallel signalling information into cell fate decisions. However, discovering the mechanisms by which stem cells respond to inherent material characteristics is challenging because of the highly complex, multicomponent signalling milieu present in the stem cell environment. In this Review, we discuss recent evidence that shows that inherent material properties may be engineered to dictate stem cell fate decisions, and overview a subset of the operative signal transduction mechanisms that have begun to emerge. Further developments in stem cell engineering and mechanotransduction are poised to have substantial implications for stem cell biology and regenerative medicine." @default.
• W1967188390 created "2016-06-24" @default.
• W1967188390 creator A5024616884 @default.
• W1967188390 creator A5039405858 @default.
• W1967188390 creator A5081705219 @default.
• W1967188390 date "2014-05-21" @default.
• W1967188390 modified "2023-10-04" @default.
• W1967188390 title "Materials as stem cell regulators" @default.
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