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- W1967204394 abstract "Intracellular microelectrodes were used to study the electrophysiological effects of U-50,488H on guinea-pig papillary muscle. U-50,488H (10(-5) M) caused a significant decrease in the maximum rate of depolarization and a decrease in the action potential duration. At high concentration (5 x 10(-5) M) U-50,488H induced a significant decrease of resting potential, maximum rate of depolarization, action potential amplitude and the action potential duration. The administration of MR-2266 (5 x 10(-7) M) partially antagonized the cardiac electrophysiological effects of U-50,488H. These results suggest that the electrophysiological effects of U-50,488H may be partially due to an interaction with opioid receptors." @default.
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- W1967204394 date "1993-05-01" @default.
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- W1967204394 title "Cardiac electrophysiological effects of U-50,488H on guinea-pig papillary muscle" @default.
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- W1967204394 doi "https://doi.org/10.1016/0143-4179(93)90021-2" @default.
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