FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967206238> ?p ?o ?g. }

• W1967206238 endingPage "43" @default.
• W1967206238 startingPage "34" @default.
• W1967206238 abstract "The aim of this study was to establish a novel adenovirus-based gene therapy system targeting astrocytoma. For this purpose, the Cre recombinase (Cre)/loxP system together with the astrocytoma-specific promoter for GFAP were used. We constructed an adenovirus (Ad) vector that expressed Cre under the control of the GFAP promoter (AxGFAPNCre), as well as another Ad vector containing a switching unit. The latter vector contained a stuffer sequence encoding GFP (AxCALGLTK) with a functional polyadenylation signal between two loxP sites, followed by the herpes simplex virus thymidine kinase (HSV-TK) gene under the control of the CAG promoter. In this system, gene expression of either the stuffer sequence (GFP) or the downstream gene (HSV-TK) was switched on by co-expression of Cre recombinase. Western blot analysis demonstrated specific expression of high levels of TK protein in C6 glioma cells after co-infection of AxGFAPNCre and AxCALGLTK. In vivo, AxGFAPNCre/AxCALGLTK injection into C6 gliomas in the subcutaneous tissue of nude mice followed by intraperitoneal ganciclovir (GCV) treatment significantly suppressed tumor growth compared with control mice. Co-infection of AxGFAPNCre and AxCALNLLacZ resulted in LacZ expression in C6 glioma cells and some reactive astrocytes, whereas GFP was expressed in other cell types surrounding the injected site. Furthermore, a combination of AxGFAPNCre/AxCALGLTK and intraperitoneal GCV injection significantly regressed intracranial C6 gliomas in the rat striatum and prolonged the survival time compared with control rats. The present results indicate that this cell-type-specific gene therapy using a Cre/loxP adenovirus system is both operational and effective, at least against astrocytoma." @default.
• W1967206238 created "2016-06-24" @default.
• W1967206238 creator A5005560558 @default.
• W1967206238 creator A5008321167 @default.
• W1967206238 creator A5021867140 @default.
• W1967206238 creator A5037866980 @default.
• W1967206238 creator A5056799905 @default.
• W1967206238 creator A5075627852 @default.
• W1967206238 creator A5078920118 @default.
• W1967206238 creator A5082083173 @default.
• W1967206238 date "2006-04-01" @default.
• W1967206238 modified "2023-10-18" @default.
• W1967206238 title "Targeted gene therapy toward astrocytoma using a Cre/loxP-based adenovirus system" @default.
• W1967206238 cites W1586539673 @default.
• W1967206238 cites W1593489191 @default.
• W1967206238 cites W1880770180 @default.
• W1967206238 cites W1968074776 @default.
• W1967206238 cites W1971213127 @default.
• W1967206238 cites W1976304868 @default.
• W1967206238 cites W1978438689 @default.
• W1967206238 cites W1980890790 @default.
• W1967206238 cites W2003232012 @default.
• W1967206238 cites W2007318225 @default.
• W1967206238 cites W2012315955 @default.
• W1967206238 cites W2016138321 @default.
• W1967206238 cites W2021667186 @default.
• W1967206238 cites W2035051990 @default.
• W1967206238 cites W2047275511 @default.
• W1967206238 cites W2052619273 @default.
• W1967206238 cites W2055825871 @default.
• W1967206238 cites W2057236931 @default.
• W1967206238 cites W2067379696 @default.
• W1967206238 cites W2071772924 @default.
• W1967206238 cites W2074762435 @default.
• W1967206238 cites W2081863993 @default.
• W1967206238 cites W2086231230 @default.
• W1967206238 cites W2086364889 @default.
• W1967206238 cites W2095414706 @default.
• W1967206238 cites W2109540013 @default.
• W1967206238 cites W2116008939 @default.
• W1967206238 cites W2126707307 @default.
• W1967206238 cites W2313269464 @default.
• W1967206238 cites W2317043514 @default.
• W1967206238 cites W2331057442 @default.
• W1967206238 doi "https://doi.org/10.1016/j.brainres.2006.01.105" @default.
• W1967206238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16529724" @default.
• W1967206238 hasPublicationYear "2006" @default.
• W1967206238 type Work @default.
• W1967206238 sameAs 1967206238 @default.
• W1967206238 citedByCount "17" @default.
• W1967206238 countsByYear W19672062382012 @default.
• W1967206238 countsByYear W19672062382014 @default.
• W1967206238 countsByYear W19672062382015 @default.
• W1967206238 countsByYear W19672062382017 @default.
• W1967206238 crossrefType "journal-article" @default.
• W1967206238 hasAuthorship W1967206238A5005560558 @default.
• W1967206238 hasAuthorship W1967206238A5008321167 @default.
• W1967206238 hasAuthorship W1967206238A5021867140 @default.
• W1967206238 hasAuthorship W1967206238A5037866980 @default.
• W1967206238 hasAuthorship W1967206238A5056799905 @default.
• W1967206238 hasAuthorship W1967206238A5075627852 @default.
• W1967206238 hasAuthorship W1967206238A5078920118 @default.
• W1967206238 hasAuthorship W1967206238A5082083173 @default.
• W1967206238 hasConcept C102230213 @default.
• W1967206238 hasConcept C104317684 @default.
• W1967206238 hasConcept C111599444 @default.
• W1967206238 hasConcept C125929170 @default.
• W1967206238 hasConcept C141035611 @default.
• W1967206238 hasConcept C142613039 @default.
• W1967206238 hasConcept C153911025 @default.
• W1967206238 hasConcept C2778227246 @default.
• W1967206238 hasConcept C32470452 @default.
• W1967206238 hasConcept C40767141 @default.
• W1967206238 hasConcept C502942594 @default.
• W1967206238 hasConcept C54355233 @default.
• W1967206238 hasConcept C86803240 @default.
• W1967206238 hasConceptScore W1967206238C102230213 @default.
• W1967206238 hasConceptScore W1967206238C104317684 @default.
• W1967206238 hasConceptScore W1967206238C111599444 @default.
• W1967206238 hasConceptScore W1967206238C125929170 @default.
• W1967206238 hasConceptScore W1967206238C141035611 @default.
• W1967206238 hasConceptScore W1967206238C142613039 @default.
• W1967206238 hasConceptScore W1967206238C153911025 @default.
• W1967206238 hasConceptScore W1967206238C2778227246 @default.
• W1967206238 hasConceptScore W1967206238C32470452 @default.
• W1967206238 hasConceptScore W1967206238C40767141 @default.
• W1967206238 hasConceptScore W1967206238C502942594 @default.
• W1967206238 hasConceptScore W1967206238C54355233 @default.
• W1967206238 hasConceptScore W1967206238C86803240 @default.
• W1967206238 hasIssue "1" @default.
• W1967206238 hasLocation W19672062381 @default.
• W1967206238 hasLocation W19672062382 @default.
• W1967206238 hasOpenAccess W1967206238 @default.
• W1967206238 hasPrimaryLocation W19672062381 @default.
• W1967206238 hasRelatedWork W1526674090 @default.
• W1967206238 hasRelatedWork W2008009288 @default.
• W1967206238 hasRelatedWork W2031633400 @default.
• W1967206238 hasRelatedWork W2059006149 @default.

• next