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- W1967211364 abstract "A hybrid Monte Carlo transport scheme combining event-by-event and condensed-history simulation with a full account of energy-loss straggling was used to study the dosimetric characteristics of the Auger-emitting radionuclides 67Ga, 99mTc, 111In, 123I, 125I and 201Tl at the single-cell level. The influence of the intracellular localization of the Auger radionuclide upon cellular S-values, radial dose rate profiles and dose-volume-histograms (DVHs) was investigated. For the case where the radiopharmaceutical was either internalized into the cytoplasm or remained bound onto the cell surface (non-internalized), the dose to the cell nucleus was found to differ significantly from the MIRD values and other published data. In this case, the assumption of a homogeneous distribution throughout the cell is shown to significantly overestimate the nuclear dose. A dosimetric case study relevant to the radioimmunotherapy of single lymphoma B-cells with 125I and 123I is presented." @default.
- W1967211364 created "2016-06-24" @default.
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- W1967211364 date "2010-04-14" @default.
- W1967211364 modified "2023-10-01" @default.
- W1967211364 title "Monte Carlo single-cell dosimetry of Auger-electron emitting radionuclides" @default.
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- W1967211364 doi "https://doi.org/10.1088/0031-9155/55/9/009" @default.
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