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• W1967216529 endingPage "e59009" @default.
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• W1967216529 abstract "Interleukin (IL)-22 has been reported to be involved in the development of autoimmune diseases. This study aimed to analyze the expression and potential role of IL-22 in the pathogenesis of Behcet's disease (BD).The levels of IL-22 in patient sera or supernatants of cultured peripheral blood mononuclear cells (PBMCs) and CD4(+)T cells were detected by enzyme-linked immunosorbent assay (ELISA). Flow cytometry was used to evaluate the frequency of IL-22-producing CD4(+) T cells. IL-22 mRNA from erythema nodosum skin lesions was examined using real time quantitative RT-PCR.BD patients with active uveitis showed a significantly higher expression of IL-22 in the supernatants of stimulated PBMCs and CD4(+)T cells compared with BD patients without active uveitis and normal controls. An increased frequency of IL-22-producing CD4(+)T cells was also found in BD patients with active uveitis. IL-22 mRNA expression was elevated in erythema nodosum skin lesions. In BD patients, a high IL-22 level in the supernatant of stimulated PBMCs correlated with the presence of retinal vasculitis and erythema nodosum.IL-22 was associated with disease activity in BD and correlated with the presence of small vessel inflammation, suggesting that it may be involved in its pathogenesis." @default.
• W1967216529 created "2016-06-24" @default.
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• W1967216529 date "2013-03-19" @default.
• W1967216529 modified "2023-10-13" @default.
• W1967216529 title "Increased Expression of IL-22 Is Associated with Disease Activity in Behcet’s Disease" @default.
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• W1967216529 doi "https://doi.org/10.1371/journal.pone.0059009" @default.
• W1967216529 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3602549" @default.
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