Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967230655> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1967230655 endingPage "43" @default.
- W1967230655 startingPage "35" @default.
- W1967230655 abstract "An increased interest in non-injectable dosage forms for polypeptides has led to identification of some compounds which can increase absorption of these drugs. Sodium salicylate administered in rectal suppositories with recombinant methionyl human growth hormone (met-hGH) lead to measurable serum concentrations and demonstratable biological activity of the polypeptide. Sodium salicylate and mineral oil were tested in the ligated stomach, duodenum, ileum and colon of rats for their ability to enhance absorption of met-hGH. Rats were injected in one of the segments of the gastrointestinal tract with 3 mgkg of met-hGH with or without sodium salicylate in aqueous buffer or mineral oil vehicle. Blood samples were collected at various time points and assayed for hGH. Absolute bioavailabilities calculated for each formulation in each intestinal segment indicated that the only treatment with greater than 3% bioavailability was injection of sodium salicylate in mineral oil into the ileum (7%) and colon (9.5%). Statistical analysis proved the surprising interaction of salicylate and mineral oil to be synergistic in absorption enhancement. This is a promising finding but several issues must be addressed and pharmaceutical formulations must be optimized before it can be developed into an oral dosage form for polypeptide drugs." @default.
- W1967230655 created "2016-06-24" @default.
- W1967230655 creator A5028351026 @default.
- W1967230655 creator A5050473309 @default.
- W1967230655 creator A5071369844 @default.
- W1967230655 date "1986-12-01" @default.
- W1967230655 modified "2023-10-17" @default.
- W1967230655 title "Absorption enhancement of growth hormone from the gastrointestinal tract of rats" @default.
- W1967230655 cites W1534500384 @default.
- W1967230655 cites W1977502947 @default.
- W1967230655 cites W1994416898 @default.
- W1967230655 cites W2035090369 @default.
- W1967230655 cites W2071853664 @default.
- W1967230655 cites W2074658813 @default.
- W1967230655 cites W2083700148 @default.
- W1967230655 cites W2130897215 @default.
- W1967230655 cites W2400342548 @default.
- W1967230655 cites W2461051517 @default.
- W1967230655 doi "https://doi.org/10.1016/0378-5173(86)90007-4" @default.
- W1967230655 hasPublicationYear "1986" @default.
- W1967230655 type Work @default.
- W1967230655 sameAs 1967230655 @default.
- W1967230655 citedByCount "35" @default.
- W1967230655 countsByYear W19672306552014 @default.
- W1967230655 countsByYear W19672306552016 @default.
- W1967230655 countsByYear W19672306552021 @default.
- W1967230655 crossrefType "journal-article" @default.
- W1967230655 hasAuthorship W1967230655A5028351026 @default.
- W1967230655 hasAuthorship W1967230655A5050473309 @default.
- W1967230655 hasAuthorship W1967230655A5071369844 @default.
- W1967230655 hasConcept C121332964 @default.
- W1967230655 hasConcept C125287762 @default.
- W1967230655 hasConcept C126322002 @default.
- W1967230655 hasConcept C178790620 @default.
- W1967230655 hasConcept C181389837 @default.
- W1967230655 hasConcept C185592680 @default.
- W1967230655 hasConcept C24890656 @default.
- W1967230655 hasConcept C2776366702 @default.
- W1967230655 hasConcept C2776809568 @default.
- W1967230655 hasConcept C2777226302 @default.
- W1967230655 hasConcept C2779134981 @default.
- W1967230655 hasConcept C2780512811 @default.
- W1967230655 hasConcept C43617362 @default.
- W1967230655 hasConcept C537181965 @default.
- W1967230655 hasConcept C55493867 @default.
- W1967230655 hasConcept C71924100 @default.
- W1967230655 hasConcept C77281830 @default.
- W1967230655 hasConcept C98274493 @default.
- W1967230655 hasConceptScore W1967230655C121332964 @default.
- W1967230655 hasConceptScore W1967230655C125287762 @default.
- W1967230655 hasConceptScore W1967230655C126322002 @default.
- W1967230655 hasConceptScore W1967230655C178790620 @default.
- W1967230655 hasConceptScore W1967230655C181389837 @default.
- W1967230655 hasConceptScore W1967230655C185592680 @default.
- W1967230655 hasConceptScore W1967230655C24890656 @default.
- W1967230655 hasConceptScore W1967230655C2776366702 @default.
- W1967230655 hasConceptScore W1967230655C2776809568 @default.
- W1967230655 hasConceptScore W1967230655C2777226302 @default.
- W1967230655 hasConceptScore W1967230655C2779134981 @default.
- W1967230655 hasConceptScore W1967230655C2780512811 @default.
- W1967230655 hasConceptScore W1967230655C43617362 @default.
- W1967230655 hasConceptScore W1967230655C537181965 @default.
- W1967230655 hasConceptScore W1967230655C55493867 @default.
- W1967230655 hasConceptScore W1967230655C71924100 @default.
- W1967230655 hasConceptScore W1967230655C77281830 @default.
- W1967230655 hasConceptScore W1967230655C98274493 @default.
- W1967230655 hasIssue "1-2" @default.
- W1967230655 hasLocation W19672306551 @default.
- W1967230655 hasOpenAccess W1967230655 @default.
- W1967230655 hasPrimaryLocation W19672306551 @default.
- W1967230655 hasRelatedWork W1595866675 @default.
- W1967230655 hasRelatedWork W2002592681 @default.
- W1967230655 hasRelatedWork W2005918193 @default.
- W1967230655 hasRelatedWork W2031501611 @default.
- W1967230655 hasRelatedWork W2072145439 @default.
- W1967230655 hasRelatedWork W2096226123 @default.
- W1967230655 hasRelatedWork W2355724904 @default.
- W1967230655 hasRelatedWork W2358164269 @default.
- W1967230655 hasRelatedWork W2374229023 @default.
- W1967230655 hasRelatedWork W2408668677 @default.
- W1967230655 hasVolume "34" @default.
- W1967230655 isParatext "false" @default.
- W1967230655 isRetracted "false" @default.
- W1967230655 magId "1967230655" @default.
- W1967230655 workType "article" @default.