FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967242595> ?p ?o ?g. }

• W1967242595 endingPage "529" @default.
• W1967242595 startingPage "514" @default.
• W1967242595 abstract "Modified internucleotide linkage featuring the C3'-O-P-CH(2)-O-C4'' phosphonate grouping as an isosteric alternative to the phosphodiester C3'-O-P-O-CH(2)-C4'' bond was studied in order to learn more on its stereochemical arrangement, which we showed earlier to be of prime importance for the properties of the respective oligonucleotide analogues. Two approaches were pursued: First, the attempt to prepare the model dinucleoside phosphonate with (13)C-labeled CH(2) group present in the modified internucleotide linkage that would allow for a more detailed evaluation of the linkage conformation by NMR spectroscopy. Second, the use of ab initio calculations along with molecular dynamics (MD) simulations in order to observe the most populated conformations and specify main structural elements governing the conformational preferences. To deal with the former aim, a novel synthesis of key labeled reagent (CH(3)O)(2)P(O)(13)CH(2)OH for dimer preparation had to be elaborated using aqueous (13)C-formaldehyde. The results from both approaches were compared and found consistent." @default.
• W1967242595 created "2016-06-24" @default.
• W1967242595 creator A5011509231 @default.
• W1967242595 creator A5036984210 @default.
• W1967242595 creator A5041325691 @default.
• W1967242595 creator A5075131066 @default.
• W1967242595 date "2009-07-01" @default.
• W1967242595 modified "2023-10-18" @default.
• W1967242595 title "Conformational evaluation of labeled C3′-O-P-13CH2-O-C4″ phosphonate internucleotide linkage, a phosphodiester isostere" @default.
• W1967242595 cites W1503667354 @default.
• W1967242595 cites W1970650788 @default.
• W1967242595 cites W1975851628 @default.
• W1967242595 cites W1985319221 @default.
• W1967242595 cites W1989487251 @default.
• W1967242595 cites W1989983244 @default.
• W1967242595 cites W1996132404 @default.
• W1967242595 cites W1996848463 @default.
• W1967242595 cites W2011896002 @default.
• W1967242595 cites W2013937235 @default.
• W1967242595 cites W2018409259 @default.
• W1967242595 cites W2030094834 @default.
• W1967242595 cites W2032453263 @default.
• W1967242595 cites W2045774530 @default.
• W1967242595 cites W2052536622 @default.
• W1967242595 cites W2061805606 @default.
• W1967242595 cites W2062911181 @default.
• W1967242595 cites W2066004760 @default.
• W1967242595 cites W2067361636 @default.
• W1967242595 cites W2068934798 @default.
• W1967242595 cites W2078595925 @default.
• W1967242595 cites W2089832697 @default.
• W1967242595 cites W2092975717 @default.
• W1967242595 cites W2093697008 @default.
• W1967242595 cites W2097131232 @default.
• W1967242595 cites W2101136532 @default.
• W1967242595 cites W2122199548 @default.
• W1967242595 cites W2136729627 @default.
• W1967242595 cites W2141434700 @default.
• W1967242595 cites W2154134651 @default.
• W1967242595 cites W2155127062 @default.
• W1967242595 cites W2162533774 @default.
• W1967242595 cites W4243769046 @default.
• W1967242595 cites W2036138585 @default.
• W1967242595 doi "https://doi.org/10.1002/bip.21162" @default.
• W1967242595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19213047" @default.
• W1967242595 hasPublicationYear "2009" @default.
• W1967242595 type Work @default.
• W1967242595 sameAs 1967242595 @default.
• W1967242595 citedByCount "5" @default.
• W1967242595 countsByYear W19672425952013 @default.
• W1967242595 countsByYear W19672425952017 @default.
• W1967242595 crossrefType "journal-article" @default.
• W1967242595 hasAuthorship W1967242595A5011509231 @default.
• W1967242595 hasAuthorship W1967242595A5036984210 @default.
• W1967242595 hasAuthorship W1967242595A5041325691 @default.
• W1967242595 hasAuthorship W1967242595A5075131066 @default.
• W1967242595 hasConcept C104317684 @default.
• W1967242595 hasConcept C115624301 @default.
• W1967242595 hasConcept C129312508 @default.
• W1967242595 hasConcept C155518411 @default.
• W1967242595 hasConcept C178790620 @default.
• W1967242595 hasConcept C180000673 @default.
• W1967242595 hasConcept C180577832 @default.
• W1967242595 hasConcept C185592680 @default.
• W1967242595 hasConcept C2776403692 @default.
• W1967242595 hasConcept C2777626080 @default.
• W1967242595 hasConcept C2779546866 @default.
• W1967242595 hasConcept C38441620 @default.
• W1967242595 hasConcept C552990157 @default.
• W1967242595 hasConcept C55493867 @default.
• W1967242595 hasConcept C66974803 @default.
• W1967242595 hasConcept C67705224 @default.
• W1967242595 hasConcept C71240020 @default.
• W1967242595 hasConcept C8010536 @default.
• W1967242595 hasConceptScore W1967242595C104317684 @default.
• W1967242595 hasConceptScore W1967242595C115624301 @default.
• W1967242595 hasConceptScore W1967242595C129312508 @default.
• W1967242595 hasConceptScore W1967242595C155518411 @default.
• W1967242595 hasConceptScore W1967242595C178790620 @default.
• W1967242595 hasConceptScore W1967242595C180000673 @default.
• W1967242595 hasConceptScore W1967242595C180577832 @default.
• W1967242595 hasConceptScore W1967242595C185592680 @default.
• W1967242595 hasConceptScore W1967242595C2776403692 @default.
• W1967242595 hasConceptScore W1967242595C2777626080 @default.
• W1967242595 hasConceptScore W1967242595C2779546866 @default.
• W1967242595 hasConceptScore W1967242595C38441620 @default.
• W1967242595 hasConceptScore W1967242595C552990157 @default.
• W1967242595 hasConceptScore W1967242595C55493867 @default.
• W1967242595 hasConceptScore W1967242595C66974803 @default.
• W1967242595 hasConceptScore W1967242595C67705224 @default.
• W1967242595 hasConceptScore W1967242595C71240020 @default.
• W1967242595 hasConceptScore W1967242595C8010536 @default.
• W1967242595 hasIssue "7" @default.
• W1967242595 hasLocation W19672425951 @default.
• W1967242595 hasLocation W19672425952 @default.
• W1967242595 hasOpenAccess W1967242595 @default.
• W1967242595 hasPrimaryLocation W19672425951 @default.
• W1967242595 hasRelatedWork W1967242595 @default.

• next