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• W1967242750 abstract "In the past few decades, the in situ sustained drug delivery platforms present fascinating potential in sentinel chemotherapy of various solid tumors. In this work, doxorubicin (DOX), a model antitumor drug, was loaded into the thermogel of poly(lactide- co -glycolide)- block -poly(ethylene glycol)- block -poly(lactide- co -glycolide). The moderate mechanical property of DOX-loaded hydrogel was confirmed by rheological test. In vitro degradation revealed the good biodegradability of thermogel. The DOX-loaded hydrogel exhibited the sustained release profiles up to 30 days without and even with elastase. The improved in vivo tumor inhibition and reduced side-effects were observed in the DOX-incorporated hydrogel group compared with those in free DOX group. The excellent in vivo results were further confirmed by the histopathological evaluation or terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay. The thermogel with great prospect may be used as an ideal controlled drug delivery platform for the designated and long-term antitumor chemotherapy. • Doxorubicin was loaded into the thermogelling hydrogel through direct dispersion. • The drug-loaded thermogel exhibited the appropriate mechanical property and biodegradability. • The doxorubicin-loaded thermogel showed the sustained payload release up to 30 days. • The enhanced in vivo antitumor efficacy and security of laden thermogel were demonstrated." @default.
• W1967242750 created "2016-06-24" @default.
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• W1967242750 date "2015-04-01" @default.
• W1967242750 modified "2023-10-16" @default.
• W1967242750 title "Thermogel-mediated sustained drug delivery for in situ malignancy chemotherapy" @default.
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• W1967242750 doi "https://doi.org/10.1016/j.msec.2015.01.026" @default.
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