FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967254425> ?p ?o ?g. }

• W1967254425 endingPage "659" @default.
• W1967254425 startingPage "652" @default.
• W1967254425 abstract "To characterize the multidrug resistance (MDR) phenotype in human oral squamous cell carcinomas (OSCCs), the expression levels of four MDR-related genes (multidrug resistance, mdr1; multidrug resistance-associated protein, MRP; glutathione S-transferase-pi, GST-pi; and DNA topoisomerase II, topoII) were analyzed in OSCCs. Fifty-two OSCC tissues and 22 normal oral mucosal tissues were involved in this study. The expression of each gene was analyzed with a reverse-transcription polymerase chain reaction (RT-PCR) method using beta(2)m microglobulin (beta(2)m) mRNA as an endogenous control. The mean values of mdr1, MRP, GST-pi, and topoII gene expression relative to the beta(2)m gene in OSCC tissues were 0.37, 0.75, 0.66, and 1.11; those of normal oral mucosa were 0.40, 0.27, 0.62, and 0.91, respectively. The averaged expression levels of the MRP and topoII gene in OSCC tissues were higher than those of normal oral mucosas (P=0.001 and P=0.02, respectively). The expression levels of four MDR-related genes in OSCCs were not related with the degree of histologic cell differentiation, tumor stage, primary or recurred tumor, or the presence or absence of chemotherapy. Linear regression analysis showed a correlation between the expression levels of MRP and GST-pi in normal oral mucosas (r=0.596, P=0.003) and in OSCCs (r=0.287, P=0.039). The results suggest that MRP expression is activated during the tumorigenesis of OSCCs and that this may play a role in de novo drug resistance in OSCCs. These results should provide further insight into the complex role postulated for MDR-related genes in chemotherapy, carcinogenesis and tumor progression." @default.
• W1967254425 created "2016-06-24" @default.
• W1967254425 creator A5005253862 @default.
• W1967254425 creator A5072577369 @default.
• W1967254425 date "2001-12-01" @default.
• W1967254425 modified "2023-09-27" @default.
• W1967254425 title "Expression of multidrug resistance-related genes in oral squamous cell carcinomas" @default.
• W1967254425 cites W1595867557 @default.
• W1967254425 cites W1792058374 @default.
• W1967254425 cites W1971628181 @default.
• W1967254425 cites W1972062962 @default.
• W1967254425 cites W1977351450 @default.
• W1967254425 cites W1989464709 @default.
• W1967254425 cites W2001258296 @default.
• W1967254425 cites W2006066600 @default.
• W1967254425 cites W2012841076 @default.
• W1967254425 cites W2025296922 @default.
• W1967254425 cites W2031066698 @default.
• W1967254425 cites W2052826841 @default.
• W1967254425 cites W2060406303 @default.
• W1967254425 cites W2063647772 @default.
• W1967254425 cites W2069943574 @default.
• W1967254425 cites W2070256254 @default.
• W1967254425 cites W2076149108 @default.
• W1967254425 cites W2078998991 @default.
• W1967254425 cites W2092807177 @default.
• W1967254425 cites W2095654922 @default.
• W1967254425 cites W2116630730 @default.
• W1967254425 cites W2134812217 @default.
• W1967254425 cites W2138136169 @default.
• W1967254425 cites W2149994120 @default.
• W1967254425 cites W2150403997 @default.
• W1967254425 cites W2165594237 @default.
• W1967254425 cites W2167621975 @default.
• W1967254425 cites W2168095256 @default.
• W1967254425 cites W2424966230 @default.
• W1967254425 doi "https://doi.org/10.1016/s1368-8375(00)00128-7" @default.
• W1967254425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11590075" @default.
• W1967254425 hasPublicationYear "2001" @default.
• W1967254425 type Work @default.
• W1967254425 sameAs 1967254425 @default.
• W1967254425 citedByCount "10" @default.
• W1967254425 countsByYear W19672544252014 @default.
• W1967254425 countsByYear W19672544252015 @default.
• W1967254425 countsByYear W19672544252016 @default.
• W1967254425 countsByYear W19672544252022 @default.
• W1967254425 crossrefType "journal-article" @default.
• W1967254425 hasAuthorship W1967254425A5005253862 @default.
• W1967254425 hasAuthorship W1967254425A5072577369 @default.
• W1967254425 hasConcept C104317684 @default.
• W1967254425 hasConcept C114851261 @default.
• W1967254425 hasConcept C121608353 @default.
• W1967254425 hasConcept C133936738 @default.
• W1967254425 hasConcept C142724271 @default.
• W1967254425 hasConcept C1491633281 @default.
• W1967254425 hasConcept C150194340 @default.
• W1967254425 hasConcept C153911025 @default.
• W1967254425 hasConcept C2994460389 @default.
• W1967254425 hasConcept C4692481 @default.
• W1967254425 hasConcept C502942594 @default.
• W1967254425 hasConcept C54355233 @default.
• W1967254425 hasConcept C555283112 @default.
• W1967254425 hasConcept C71924100 @default.
• W1967254425 hasConcept C86803240 @default.
• W1967254425 hasConceptScore W1967254425C104317684 @default.
• W1967254425 hasConceptScore W1967254425C114851261 @default.
• W1967254425 hasConceptScore W1967254425C121608353 @default.
• W1967254425 hasConceptScore W1967254425C133936738 @default.
• W1967254425 hasConceptScore W1967254425C142724271 @default.
• W1967254425 hasConceptScore W1967254425C1491633281 @default.
• W1967254425 hasConceptScore W1967254425C150194340 @default.
• W1967254425 hasConceptScore W1967254425C153911025 @default.
• W1967254425 hasConceptScore W1967254425C2994460389 @default.
• W1967254425 hasConceptScore W1967254425C4692481 @default.
• W1967254425 hasConceptScore W1967254425C502942594 @default.
• W1967254425 hasConceptScore W1967254425C54355233 @default.
• W1967254425 hasConceptScore W1967254425C555283112 @default.
• W1967254425 hasConceptScore W1967254425C71924100 @default.
• W1967254425 hasConceptScore W1967254425C86803240 @default.
• W1967254425 hasIssue "8" @default.
• W1967254425 hasLocation W19672544251 @default.
• W1967254425 hasLocation W19672544252 @default.
• W1967254425 hasOpenAccess W1967254425 @default.
• W1967254425 hasPrimaryLocation W19672544251 @default.
• W1967254425 hasRelatedWork W1499339123 @default.
• W1967254425 hasRelatedWork W2009966535 @default.
• W1967254425 hasRelatedWork W2056172754 @default.
• W1967254425 hasRelatedWork W2065690661 @default.
• W1967254425 hasRelatedWork W2117059884 @default.
• W1967254425 hasRelatedWork W2467622083 @default.
• W1967254425 hasRelatedWork W2487824964 @default.
• W1967254425 hasRelatedWork W2769390123 @default.
• W1967254425 hasRelatedWork W2984941165 @default.
• W1967254425 hasRelatedWork W4323808922 @default.
• W1967254425 hasVolume "37" @default.
• W1967254425 isParatext "false" @default.
• W1967254425 isRetracted "false" @default.
• W1967254425 magId "1967254425" @default.

• next