FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967257247> ?p ?o ?g. }

• W1967257247 endingPage "768" @default.
• W1967257247 startingPage "764" @default.
• W1967257247 abstract "1 We have examined the mechanisms by which the K+-channel blocker 4-aminopyridine (4-AP) can dose-dependently increase both basal [3H]-noradrenaline ([3H]-NA) release and the [3H]-NA release evoked by electrical stimulation, but not the release of [3H]-acetylcholine ([3H]-ACh), from slices of rat hippocampus. 2 Both the electrically evoked and the 4-AP-induced release were blocked by tetrodotoxin (TTX) (3 μm). The Ca2+-dependence of the 4-AP-induced release (EC50 0.15 mm) was, however, different from that of the electrically evoked [3H]-NA release (EC50 0.76 mm). 3 The 4-AP-induced release could be inhibited by CdCl2(10 μm) and ω-conotoxin (30 nm), but not by nifedipine (1 μm). 4 Transmitter release evoked by 100 μm 4-AP could be blocked by the α2-adrenoceptor agonist, UK 14,304 (0.1 μm) and by the A1-receptor agonist R-N6-phenylisopropyl adenosine (R-PIA, 1 μm) and increased by the α2-adrenoceptor antagonist, yohimbine (1 μm), both in 0.25 and 1.3 mm Ca2+-containing medium. By contrast, the effect of α2-adrenoceptor agonists and antagonists on transmitter release evoked by electrical stimulation was markedly reduced in the presence of 4-AP (100 μm). 5 The results suggest that 4-AP can depolarize some nerve endings in the central nervous system, leading to transmitter release that is dependent on nerve impulses and Ca2+. Furthermore, the fact that α2-receptors and adenosine A1 receptor agonists can influence the release of NA evoked by 4-AP suggests that these drugs may have actions that are independent of blockade of aminopyridine-sensitive K+-channels." @default.
• W1967257247 created "2016-06-24" @default.
• W1967257247 creator A5008327136 @default.
• W1967257247 creator A5040115754 @default.
• W1967257247 date "1991-03-01" @default.
• W1967257247 modified "2023-10-16" @default.
• W1967257247 title "4-Aminopyridine-induced increase in basal and stimulation-evoked [3H]-NA release in slices from rat hippocampus: Ca2+ sensitivity and presynaptic control" @default.
• W1967257247 cites W1496211185 @default.
• W1967257247 cites W180111337 @default.
• W1967257247 cites W186417911 @default.
• W1967257247 cites W1972679916 @default.
• W1967257247 cites W1976763631 @default.
• W1967257247 cites W1977592396 @default.
• W1967257247 cites W1987907651 @default.
• W1967257247 cites W1988604209 @default.
• W1967257247 cites W2007990537 @default.
• W1967257247 cites W2008940140 @default.
• W1967257247 cites W2016562649 @default.
• W1967257247 cites W2018564670 @default.
• W1967257247 cites W2026404583 @default.
• W1967257247 cites W2037747335 @default.
• W1967257247 cites W2038910392 @default.
• W1967257247 cites W2041323061 @default.
• W1967257247 cites W2045209711 @default.
• W1967257247 cites W2045912164 @default.
• W1967257247 cites W2055991501 @default.
• W1967257247 cites W2062963816 @default.
• W1967257247 cites W2077590594 @default.
• W1967257247 cites W2082034473 @default.
• W1967257247 cites W2085872157 @default.
• W1967257247 cites W2086670234 @default.
• W1967257247 cites W2095582986 @default.
• W1967257247 cites W2116530915 @default.
• W1967257247 cites W2122442918 @default.
• W1967257247 cites W2412563585 @default.
• W1967257247 cites W2414424124 @default.
• W1967257247 cites W72363943 @default.
• W1967257247 doi "https://doi.org/10.1111/j.1476-5381.1991.tb12247.x" @default.
• W1967257247 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1917950" @default.
• W1967257247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1364850" @default.
• W1967257247 hasPublicationYear "1991" @default.
• W1967257247 type Work @default.
• W1967257247 sameAs 1967257247 @default.
• W1967257247 citedByCount "27" @default.
• W1967257247 countsByYear W19672572472013 @default.
• W1967257247 countsByYear W19672572472015 @default.
• W1967257247 crossrefType "journal-article" @default.
• W1967257247 hasAuthorship W1967257247A5008327136 @default.
• W1967257247 hasAuthorship W1967257247A5040115754 @default.
• W1967257247 hasBestOaLocation W19672572471 @default.
• W1967257247 hasConcept C126322002 @default.
• W1967257247 hasConcept C134018914 @default.
• W1967257247 hasConcept C170493617 @default.
• W1967257247 hasConcept C185592680 @default.
• W1967257247 hasConcept C24998067 @default.
• W1967257247 hasConcept C2775910092 @default.
• W1967257247 hasConcept C2776741303 @default.
• W1967257247 hasConcept C2776885963 @default.
• W1967257247 hasConcept C2776991684 @default.
• W1967257247 hasConcept C2777676773 @default.
• W1967257247 hasConcept C2778938600 @default.
• W1967257247 hasConcept C2780019924 @default.
• W1967257247 hasConcept C2780922449 @default.
• W1967257247 hasConcept C55493867 @default.
• W1967257247 hasConcept C71924100 @default.
• W1967257247 hasConcept C83743174 @default.
• W1967257247 hasConcept C86803240 @default.
• W1967257247 hasConceptScore W1967257247C126322002 @default.
• W1967257247 hasConceptScore W1967257247C134018914 @default.
• W1967257247 hasConceptScore W1967257247C170493617 @default.
• W1967257247 hasConceptScore W1967257247C185592680 @default.
• W1967257247 hasConceptScore W1967257247C24998067 @default.
• W1967257247 hasConceptScore W1967257247C2775910092 @default.
• W1967257247 hasConceptScore W1967257247C2776741303 @default.
• W1967257247 hasConceptScore W1967257247C2776885963 @default.
• W1967257247 hasConceptScore W1967257247C2776991684 @default.
• W1967257247 hasConceptScore W1967257247C2777676773 @default.
• W1967257247 hasConceptScore W1967257247C2778938600 @default.
• W1967257247 hasConceptScore W1967257247C2780019924 @default.
• W1967257247 hasConceptScore W1967257247C2780922449 @default.
• W1967257247 hasConceptScore W1967257247C55493867 @default.
• W1967257247 hasConceptScore W1967257247C71924100 @default.
• W1967257247 hasConceptScore W1967257247C83743174 @default.
• W1967257247 hasConceptScore W1967257247C86803240 @default.
• W1967257247 hasIssue "3" @default.
• W1967257247 hasLocation W19672572471 @default.
• W1967257247 hasLocation W19672572472 @default.
• W1967257247 hasLocation W19672572473 @default.
• W1967257247 hasLocation W19672572474 @default.
• W1967257247 hasOpenAccess W1967257247 @default.
• W1967257247 hasPrimaryLocation W19672572471 @default.
• W1967257247 hasRelatedWork W1967257247 @default.
• W1967257247 hasRelatedWork W2011605302 @default.
• W1967257247 hasRelatedWork W2026404583 @default.
• W1967257247 hasRelatedWork W2027913950 @default.
• W1967257247 hasRelatedWork W2054992011 @default.
• W1967257247 hasRelatedWork W2064416809 @default.
• W1967257247 hasRelatedWork W2065224155 @default.

• next