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• W1967280337 abstract "The appendix as well as the small intestine have recently been found to carry c‐kit + stem cells which give rise to extrathymic T cells. In this study, the properties of c‐kit + stem cells in the appendix of mice were further characterized. When appendix mononuclear cells (MNC) were cultured in the presence of stem cell factor, interleukin‐3, interleukin‐6 and erythropoietin on a methylcellulose culture plate, the population of c‐kit dull Lin − and that of c‐kit hi Lin − cells expanded. Morphological study revealed that these c‐kit hi Lin − cells were basophilic granular cells (possibly mast cells). Both populations of cultured appendix MNC were then injected into severe combined immunodeficient mice or cultured with Tst‐4 thymic stroma cells. These in vivo and in vitro studies demonstrated that c‐kit dull Lin − cells were oligopotent haemopoietic progenitor cells which gave rise to extrathymic T cells, while c‐kit hi Lin − cells lacked haemopoietic progenitor cell activity. In contrast to c‐kit + stem cells in the bone marrow, those in the appendix did not give rise to myeloid cells and conventional thymic T cells under any of the conditions tested. The present results suggest that the appendix primarily comprises c‐kit + cells which give rise to basophilic granular cells and extrathymic T cells and that such c‐kit + cells have the ability to replicate themselves in culture in vitro ." @default.
• W1967280337 created "2016-06-24" @default.
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• W1967280337 date "1999-03-01" @default.
• W1967280337 modified "2023-10-16" @default.
• W1967280337 title "Enrichment of c‐kit⁺Lin⁻haemopoietic progenitor cells that commit themselves to extrathymic T cells in<i>in vitro</i>culture of appendix mononuclear cells" @default.
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• W1967280337 doi "https://doi.org/10.1046/j.1365-2567.1999.00686.x" @default.
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