Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967283851> ?p ?o ?g. }
- W1967283851 endingPage "91" @default.
- W1967283851 startingPage "91" @default.
- W1967283851 abstract "Critical appraisal of amlodipine and olmesartan medoxomil fixed-dose combination in achieving blood pressure goals Jan BasileProfessor of Medicine, Medical University of South Carolina, Charleston, SC, USAAbstract: Hypertension remains a significant health burden in the United States, with almost one in three adults affected, and is an independent risk factor for cardiovascular and renal disease. The goal of antihypertensive treatment is to reduce cardiovascular and renal morbidity and mortality by reducing blood pressure (BP). Guidelines recommend a target BP of <140/90 mmHg, with a more stringent goal of <130/80 mmHg for patients with diabetes and chronic renal disease. However, BP goal attainment rates remain low and most patients require therapy with two or more antihypertensive agents. Combination antihypertensive therapy usually employs agents from different classes, thus benefitting from complementary mechanisms of action to achieve greater BP control with fewer side effects. Patient adherence to therapy is enhanced by formulating treatments as fixed-dose (single-pill) combinations. One example is the combination of amlodipine, a dihydropyridine calcium channel blocker (CCB), with olmesartan medoxomil, an angiotensin receptor blocker (ARB). Here, the rationale for the use of CCB/ARB combination therapy is discussed, as well as the pharmacology and tolerability of the amlodipine/olmesartan medoxomil combination and its efficacy in terms of achieving BP goal in patients with hypertension. Advantages of its use from the patient’s perspective are also discussed.Keywords: amlodipine, angiotensin receptor blockers, calcium channel blockers, fixed-dose combination therapy, hypertension, olmesartan medoxomil" @default.
- W1967283851 created "2016-06-24" @default.
- W1967283851 creator A5056252103 @default.
- W1967283851 date "2010-06-01" @default.
- W1967283851 modified "2023-09-30" @default.
- W1967283851 title "Critical appraisal of amlodipine and olmesartan medoxomil fixed-dose combination in achieving blood pressure goals" @default.
- W1967283851 cites W1062396113 @default.
- W1967283851 cites W1497461844 @default.
- W1967283851 cites W1675495432 @default.
- W1967283851 cites W1980670470 @default.
- W1967283851 cites W1988164721 @default.
- W1967283851 cites W1988716175 @default.
- W1967283851 cites W1992141117 @default.
- W1967283851 cites W2011780612 @default.
- W1967283851 cites W2013678571 @default.
- W1967283851 cites W2017325092 @default.
- W1967283851 cites W2021437400 @default.
- W1967283851 cites W202756716 @default.
- W1967283851 cites W2032595010 @default.
- W1967283851 cites W2035054318 @default.
- W1967283851 cites W2042282631 @default.
- W1967283851 cites W2056233199 @default.
- W1967283851 cites W2061749460 @default.
- W1967283851 cites W2063602598 @default.
- W1967283851 cites W2063743992 @default.
- W1967283851 cites W2068641704 @default.
- W1967283851 cites W2068908293 @default.
- W1967283851 cites W2069184139 @default.
- W1967283851 cites W2072251130 @default.
- W1967283851 cites W2084130233 @default.
- W1967283851 cites W2089173861 @default.
- W1967283851 cites W2092513538 @default.
- W1967283851 cites W2093398713 @default.
- W1967283851 cites W2110880027 @default.
- W1967283851 cites W2116717490 @default.
- W1967283851 cites W2120179549 @default.
- W1967283851 cites W2122326747 @default.
- W1967283851 cites W2124394654 @default.
- W1967283851 cites W2129991662 @default.
- W1967283851 cites W2133217116 @default.
- W1967283851 cites W2133416234 @default.
- W1967283851 cites W2134126803 @default.
- W1967283851 cites W2137978158 @default.
- W1967283851 cites W2144360877 @default.
- W1967283851 cites W2152798629 @default.
- W1967283851 cites W2154052522 @default.
- W1967283851 cites W2156121263 @default.
- W1967283851 cites W2158560462 @default.
- W1967283851 cites W2159946343 @default.
- W1967283851 cites W2160547085 @default.
- W1967283851 cites W2166520734 @default.
- W1967283851 cites W2172136086 @default.
- W1967283851 cites W2183969939 @default.
- W1967283851 cites W2233172817 @default.
- W1967283851 cites W2303651371 @default.
- W1967283851 cites W2324073102 @default.
- W1967283851 cites W2463829385 @default.
- W1967283851 cites W2916392902 @default.
- W1967283851 cites W48752276 @default.
- W1967283851 cites W2026953389 @default.
- W1967283851 doi "https://doi.org/10.2147/ibpc.s9691" @default.
- W1967283851 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3172072" @default.
- W1967283851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21949625" @default.
- W1967283851 hasPublicationYear "2010" @default.
- W1967283851 type Work @default.
- W1967283851 sameAs 1967283851 @default.
- W1967283851 citedByCount "5" @default.
- W1967283851 countsByYear W19672838512013 @default.
- W1967283851 countsByYear W19672838512016 @default.
- W1967283851 countsByYear W19672838512018 @default.
- W1967283851 countsByYear W19672838512022 @default.
- W1967283851 crossrefType "journal-article" @default.
- W1967283851 hasAuthorship W1967283851A5056252103 @default.
- W1967283851 hasBestOaLocation W19672838511 @default.
- W1967283851 hasConcept C104849204 @default.
- W1967283851 hasConcept C126322002 @default.
- W1967283851 hasConcept C177713679 @default.
- W1967283851 hasConcept C197934379 @default.
- W1967283851 hasConcept C2776623344 @default.
- W1967283851 hasConcept C2776999253 @default.
- W1967283851 hasConcept C2778375690 @default.
- W1967283851 hasConcept C2779066535 @default.
- W1967283851 hasConcept C2779646130 @default.
- W1967283851 hasConcept C2779716603 @default.
- W1967283851 hasConcept C2779766728 @default.
- W1967283851 hasConcept C2780356492 @default.
- W1967283851 hasConcept C2908929049 @default.
- W1967283851 hasConcept C519063684 @default.
- W1967283851 hasConcept C71924100 @default.
- W1967283851 hasConcept C84393581 @default.
- W1967283851 hasConcept C98274493 @default.
- W1967283851 hasConceptScore W1967283851C104849204 @default.
- W1967283851 hasConceptScore W1967283851C126322002 @default.
- W1967283851 hasConceptScore W1967283851C177713679 @default.
- W1967283851 hasConceptScore W1967283851C197934379 @default.
- W1967283851 hasConceptScore W1967283851C2776623344 @default.
- W1967283851 hasConceptScore W1967283851C2776999253 @default.
- W1967283851 hasConceptScore W1967283851C2778375690 @default.