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- W1967289199 abstract "In this study, we provide evidence for the first time that membrane-bound endopeptidase neurolysin is up-regulated in different parts of mouse brain affected by focal ischemia-reperfusion in a middle cerebral artery occlusion model of stroke. Radioligand binding, enzymatic and immunoblotting experiments in membrane preparations of frontoparietal cortex, striatum, and hippocampus isolated from the ischemic hemisphere of mouse brain 24 h after reperfusion revealed statistically significant increase (≥ twofold) in quantity and activity of neurolysin compared with sham-operated controls. Cerebellar membranes isolated from the ischemic hemisphere served as negative control supporting the observations that up-regulation of neurolysin occurs in post-ischemic brain regions. This study also documents sustained functional up-regulation of neurolysin in frontoparietal cortical membranes for at least 7 days after stroke, which appears not to be transcriptionally or translationally regulated, but rather depends on translocation of cytosolic neurolysin to the membranes and mitochondria. Considering diversity of endogenous neurolysin substrates (neurotensin, bradykinin, angiotensins I/II, substance P, hemopressin, dynorphin A(1-8), metorphamide, somatostatin) and the well-documented role of these peptidergic systems in pathogenesis of stroke, resistance to ischemic injury and/or post-stroke brain recovery, our findings suggest that neurolysin may play a role in processes modulating the brain's response to stroke and its recovery after stroke." @default.
- W1967289199 created "2016-06-24" @default.
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- W1967289199 date "2013-11-19" @default.
- W1967289199 modified "2023-10-14" @default.
- W1967289199 title "Functional up‐regulation of endopeptidase neurolysin during post‐acute and early recovery phases of experimental stroke in mouse brain" @default.
- W1967289199 cites W127165557 @default.
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- W1967289199 cites W1529806277 @default.
- W1967289199 cites W1577408613 @default.
- W1967289199 cites W1597912030 @default.
- W1967289199 cites W1729884812 @default.
- W1967289199 cites W1968002337 @default.
- W1967289199 cites W1968353349 @default.
- W1967289199 cites W1974515002 @default.
- W1967289199 cites W1975029183 @default.
- W1967289199 cites W1978111954 @default.
- W1967289199 cites W1984780148 @default.
- W1967289199 cites W1984950849 @default.
- W1967289199 cites W1985841848 @default.
- W1967289199 cites W1988405353 @default.
- W1967289199 cites W1991264744 @default.
- W1967289199 cites W1992237388 @default.
- W1967289199 cites W1993220836 @default.
- W1967289199 cites W1993317317 @default.
- W1967289199 cites W1994211769 @default.
- W1967289199 cites W1998151033 @default.
- W1967289199 cites W1999043545 @default.
- W1967289199 cites W2002358346 @default.
- W1967289199 cites W2005400383 @default.
- W1967289199 cites W2005572141 @default.
- W1967289199 cites W2007817980 @default.
- W1967289199 cites W2011197202 @default.
- W1967289199 cites W2011684078 @default.
- W1967289199 cites W2011783556 @default.
- W1967289199 cites W2013900800 @default.
- W1967289199 cites W2020260055 @default.
- W1967289199 cites W2021715667 @default.
- W1967289199 cites W2022690437 @default.
- W1967289199 cites W2023240976 @default.
- W1967289199 cites W2024419355 @default.
- W1967289199 cites W2024927304 @default.
- W1967289199 cites W2029768670 @default.
- W1967289199 cites W2034273710 @default.
- W1967289199 cites W2037233673 @default.
- W1967289199 cites W2038608538 @default.
- W1967289199 cites W2042379312 @default.
- W1967289199 cites W2050828219 @default.
- W1967289199 cites W2050856345 @default.
- W1967289199 cites W2052092391 @default.
- W1967289199 cites W2053074318 @default.
- W1967289199 cites W2057246312 @default.
- W1967289199 cites W2059380190 @default.
- W1967289199 cites W2060079014 @default.
- W1967289199 cites W2063541896 @default.
- W1967289199 cites W2063563646 @default.
- W1967289199 cites W2065099587 @default.
- W1967289199 cites W2069111099 @default.
- W1967289199 cites W2075577711 @default.
- W1967289199 cites W2076159931 @default.
- W1967289199 cites W2078027022 @default.
- W1967289199 cites W2087997311 @default.
- W1967289199 cites W2091157623 @default.
- W1967289199 cites W2091919125 @default.
- W1967289199 cites W2092103890 @default.
- W1967289199 cites W2094557014 @default.
- W1967289199 cites W2094971529 @default.
- W1967289199 cites W2096597907 @default.
- W1967289199 cites W2102402407 @default.
- W1967289199 cites W2112095855 @default.
- W1967289199 cites W2118200665 @default.
- W1967289199 cites W2120031987 @default.
- W1967289199 cites W2121158877 @default.
- W1967289199 cites W2130229686 @default.
- W1967289199 cites W2130938036 @default.
- W1967289199 cites W2138974986 @default.
- W1967289199 cites W2143563339 @default.
- W1967289199 cites W2145191356 @default.
- W1967289199 cites W2147243399 @default.
- W1967289199 cites W2159767417 @default.
- W1967289199 cites W2162148277 @default.
- W1967289199 cites W2168782395 @default.
- W1967289199 cites W2211789762 @default.
- W1967289199 cites W2333238186 @default.
- W1967289199 cites W4231166943 @default.
- W1967289199 cites W4292022394 @default.
- W1967289199 doi "https://doi.org/10.1111/jnc.12513" @default.
- W1967289199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24164478" @default.
- W1967289199 hasPublicationYear "2013" @default.
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