FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967305712> ?p ?o ?g. }

• W1967305712 endingPage "83" @default.
• W1967305712 startingPage "73" @default.
• W1967305712 abstract "The substitution reactions of ruthenium(II) polypyridyl complexes [Ru(Cl-tpy)(en)Cl][Cl] (1) and [Ru(Cl-tpy)(dach)Cl][Cl] (2) (Cl-tpy = 4′-chloro-2,2′:6′,2″-terpyridine, en = 1,2-diaminoethane, dach = 1,2-diaminocyclohexane), with sulfur- (thiourea, l-cysteine and l-methionine) and nitrogen-donor (pyrazole, 1,2,4-triazole and pyridine) biomolecules were studied in aqueous solutions (25 mM Hepes buffer, 30 mM NaCl, pH 7.4) by UV–Vis spectrophotometry. The aim of the study was to improve the understanding of the mechanism of action of ruthenium(II) terpyridine complexes as potential antitumor drugs. The rate of the reaction of 1 and 2 with selected ligands depends on the nature and on the charge of both the chelating and the entering ligand. The order of reactivity of investigated ligands is: thiourea > l-cysteine > pyrazole > 1,2,4-triazole > pyridine > l-methionine. The measured enthalpies and entropies of activation (ΔH≠ > 0, ΔS≠ < 0) support an associative mechanism for the substitution process. The interaction of these ruthenium(II) polypyridyl complexes with the studied ligands was also investigated by 1H NMR spectroscopy. All reactions lead, although with different rates and to different extents, to the formation of monofunctional adduct. The NMR results have revealed redox reactions of thiol adducts [Ru(Cl-tpy)(en)(SR)]+ (4) and [Ru(Cl-tpy)(dach)(SR)]+ (11) induced by Ru(II) coordination forming the sulfenato complexes [Ru(Cl-tpy)(en)(RSO)]2+ (5) and [Ru(Cl-tpy)(dach)(RSO)]2+ (12). The results from the kinetic studies were supported also by density functional theory calculations (B3LYP/LANL2DZp), which showed that guanine coordination to the ruthenium(II) terpyridine complexes is much more favored than thioether coordination. DFT calculations revealed also that the N4 coordination of 1,2,4-triazole (Tz) to the ruthenium center leads to more stable species compared to the N2 coordination, which is in accordance with the NMR findings." @default.
• W1967305712 created "2016-06-24" @default.
• W1967305712 creator A5013940117 @default.
• W1967305712 creator A5040490602 @default.
• W1967305712 creator A5056072100 @default.
• W1967305712 date "2015-05-01" @default.
• W1967305712 modified "2023-09-24" @default.
• W1967305712 title "Mechanism of the reactions of ruthenium(II) polypyridyl complexes with thiourea, sulfur-containing amino acids and nitrogen-containing heterocycles" @default.
• W1967305712 cites W1483822359 @default.
• W1967305712 cites W1946042492 @default.
• W1967305712 cites W1963570923 @default.
• W1967305712 cites W1964314803 @default.
• W1967305712 cites W1965399958 @default.
• W1967305712 cites W1966182479 @default.
• W1967305712 cites W1967013061 @default.
• W1967305712 cites W1967334772 @default.
• W1967305712 cites W1973889110 @default.
• W1967305712 cites W1979106309 @default.
• W1967305712 cites W1981327198 @default.
• W1967305712 cites W1984380827 @default.
• W1967305712 cites W1984599229 @default.
• W1967305712 cites W1985282657 @default.
• W1967305712 cites W1986585012 @default.
• W1967305712 cites W1993383767 @default.
• W1967305712 cites W1999374190 @default.
• W1967305712 cites W2001976945 @default.
• W1967305712 cites W2002194503 @default.
• W1967305712 cites W2003575529 @default.
• W1967305712 cites W2005241587 @default.
• W1967305712 cites W2005603971 @default.
• W1967305712 cites W2005723165 @default.
• W1967305712 cites W2008182120 @default.
• W1967305712 cites W2011254772 @default.
• W1967305712 cites W2014827594 @default.
• W1967305712 cites W2017356685 @default.
• W1967305712 cites W2021357316 @default.
• W1967305712 cites W2021592745 @default.
• W1967305712 cites W2023271753 @default.
• W1967305712 cites W2024859834 @default.
• W1967305712 cites W2027752922 @default.
• W1967305712 cites W2028338260 @default.
• W1967305712 cites W2035726962 @default.
• W1967305712 cites W2036640302 @default.
• W1967305712 cites W2038767330 @default.
• W1967305712 cites W2039102028 @default.
• W1967305712 cites W2039559098 @default.
• W1967305712 cites W2039597106 @default.
• W1967305712 cites W2042246520 @default.
• W1967305712 cites W2044490585 @default.
• W1967305712 cites W2047063656 @default.
• W1967305712 cites W2047855383 @default.
• W1967305712 cites W2050077837 @default.
• W1967305712 cites W2053236886 @default.
• W1967305712 cites W2056769535 @default.
• W1967305712 cites W2058825735 @default.
• W1967305712 cites W2058848030 @default.
• W1967305712 cites W2067829883 @default.
• W1967305712 cites W2068617439 @default.
• W1967305712 cites W2070732745 @default.
• W1967305712 cites W2070806213 @default.
• W1967305712 cites W2080954648 @default.
• W1967305712 cites W2085966856 @default.
• W1967305712 cites W2088208644 @default.
• W1967305712 cites W2093282189 @default.
• W1967305712 cites W2103459003 @default.
• W1967305712 cites W2122617373 @default.
• W1967305712 cites W2129213133 @default.
• W1967305712 cites W2130237005 @default.
• W1967305712 cites W2143981217 @default.
• W1967305712 cites W2146687709 @default.
• W1967305712 cites W2148284063 @default.
• W1967305712 cites W2155801971 @default.
• W1967305712 cites W2163363732 @default.
• W1967305712 cites W2328311006 @default.
• W1967305712 cites W4248313882 @default.
• W1967305712 doi "https://doi.org/10.1016/j.poly.2015.02.030" @default.
• W1967305712 hasPublicationYear "2015" @default.
• W1967305712 type Work @default.
• W1967305712 sameAs 1967305712 @default.
• W1967305712 citedByCount "16" @default.
• W1967305712 countsByYear W19673057122015 @default.
• W1967305712 countsByYear W19673057122016 @default.
• W1967305712 countsByYear W19673057122017 @default.
• W1967305712 countsByYear W19673057122018 @default.
• W1967305712 countsByYear W19673057122019 @default.
• W1967305712 countsByYear W19673057122020 @default.
• W1967305712 countsByYear W19673057122021 @default.
• W1967305712 countsByYear W19673057122022 @default.
• W1967305712 countsByYear W19673057122023 @default.
• W1967305712 crossrefType "journal-article" @default.
• W1967305712 hasAuthorship W1967305712A5013940117 @default.
• W1967305712 hasAuthorship W1967305712A5040490602 @default.
• W1967305712 hasAuthorship W1967305712A5056072100 @default.
• W1967305712 hasConcept C108204754 @default.
• W1967305712 hasConcept C111185830 @default.
• W1967305712 hasConcept C116569031 @default.
• W1967305712 hasConcept C142724271 @default.
• W1967305712 hasConcept C155647269 @default.

• next