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• W1967329423 abstract "Insulin-like growth factors (IGFs) I and II are polypeptides with an insulin-like chemical structure and insulin-like biological properties (Rinderknecht and Humbel, 1978a, 1978b). They have been isolated from human serum. Their molecular weights are 7649 and 7471. However, they do not circulate in blood as free polypeptides, but are non-covalently bound to specific carrier protein(s) (Zapf, Waldvogel and Froesch, 1975; Hintz and Liu, 1977; Zapf et al, 1978). As shown in Figure 1, 75 to 80 per cent of total immunoreactive IGFs I and II are recovered in a 150000200 000 molecular weight protein fraction after neutral Sephadex G-200 gel filtration of serum (gamma globulin-sized IGF peak, Kav 0.22-0.24), whereas the rest is found in a second protein fraction (molecular weight 50 000, Kav 0.48-0.50) which elutes after the albumin peak (albumin-sized IGF peak). Total bioassayable IGF shows the same distribution (Zapf et al, 1978). So far it has not been possible to identify free IGF in serum. Whereas the biological, immunological and receptor-binding properties of the purified polypeptides have been relatively well characterized, there is only scanty information on the properties of the native, i.e., the complexed forms of IGFs. The main reason for this is that all efficient purification procedures of IGF start with an acid-ethanol extraction or acidic gel filtration of serum in order to remove the bulk of serum proteins and to facilitate further purification. Under these conditions the IGF-carrier complexes dissociate and release low molecular weight IGFs. The latter differ essentially from the IGF-carrier complexes: the carrier protein abolishes the acute insulin-like actions typical of the free polypeptides (Meuli, Zapf and Froesch, 1978; Zapf et al, 1979), it restricts their permeability through capillaries and it inhibits their access to membrane receptors (Meuli, Zapf and Froesch, 1978; Zapf et al, 1979; Daughaday, Mariz and Blethen, 1980) and immunobinding sites (Daughaday, Mariz and Blethen, 1980). These peculiarities ought to be kept in mind when" @default.
• W1967329423 created "2016-06-24" @default.
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• W1967329423 date "1984-03-01" @default.
• W1967329423 modified "2023-10-15" @default.
• W1967329423 title "1 Biological and immunological properties of insulin-like growth factors (IGF) I and II" @default.
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• W1967329423 doi "https://doi.org/10.1016/s0300-595x(84)80006-7" @default.
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