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- W1967344517 abstract "Subterranean termites face strong pathogenic pressures from the ubiquitous soil fungus Metarhizium anisopliae, and rely on innate humoral and cellular, as well as behavioral immune defenses for protection. Reticulitermes termites secrete antifungal enzymes that exhibit strong β-1,3-glucanase activity associated with Gram-negative bacteria binding proteins (GNBPs), which prevent M. anisopliae from invading the hemocoel where it can evade immune responses. Molecular evolutionary studies of Reticulitermes termicin genes, which code for defensin-like antifungal peptides, suggest that these proteins may be important effector molecules in antifungal defenses. In this study we show that the RNAi knockdown of termicin and GNBP2 expression via the ingestion of dsRNA significantly increases mortality in termites exposed to a naturally encountered strain of M. anisopliae. Termicin and GNBP2 knockdown also decrease external cuticular antifungal activity, indicating a direct role for these proteins in an external antifungal defense strategy that depends on the active dissemination of antifungal secretions among nestmates." @default.
- W1967344517 created "2016-06-24" @default.
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- W1967344517 date "2012-02-01" @default.
- W1967344517 modified "2023-10-02" @default.
- W1967344517 title "Molecular antifungal defenses in subterranean termites: RNA interference reveals in vivo roles of termicins and GNBPs against a naturally encountered pathogen" @default.
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- W1967344517 doi "https://doi.org/10.1016/j.dci.2011.07.008" @default.
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