FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967355280> ?p ?o ?g. }

• W1967355280 endingPage "90" @default.
• W1967355280 startingPage "83" @default.
• W1967355280 abstract "Abstract The trans‐activator of transcription (TAT) peptide is regarded as the “gold standard” for cell‐penetrating peptides, capable of traversing a mammalian membrane passively into the cytosolic space. This characteristic has been exploited through conjugation of TAT for applications such as drug delivery. However, the process by which TAT achieves membrane penetration remains ambiguous and unresolved. Mechanistic details of TAT peptide action are revealed herein by using three complementary methods: quartz crystal microbalance with dissipation (QCM‐D), scanning electrochemical microscopy (SECM) and atomic force microscopy (AFM). When combined, these three scales of measurement define that the membrane uptake of the TAT peptide is by trans‐membrane insertion using a “worm‐hole” pore that leads to ion permeability across the membrane layer. AFM data provided nanometre‐scale visualisation of TAT punctuation using a mammalian‐mimetic membrane bilayer. The TAT peptide does not show the same specificity towards a bacterial mimetic membrane and QCM‐D and SECM showed that the TAT peptide demonstrates a disruptive action towards these membranes. This investigation supports the energy‐independent uptake of the cationic TAT peptide and provides empirical data that clarify the mechanism by which the TAT peptide achieves its membrane activity. The novel use of these three biophysical techniques provides valuable insight into the mechanism for TAT peptide translocation, which is essential for improvements in the cellular delivery of TAT‐conjugated cargoes including therapeutic agents required to target specific intracellular locations." @default.
• W1967355280 created "2016-06-24" @default.
• W1967355280 creator A5026737180 @default.
• W1967355280 creator A5028954833 @default.
• W1967355280 creator A5036482071 @default.
• W1967355280 creator A5037644100 @default.
• W1967355280 creator A5040934489 @default.
• W1967355280 creator A5043580508 @default.
• W1967355280 creator A5046268649 @default.
• W1967355280 creator A5050672687 @default.
• W1967355280 creator A5055403368 @default.
• W1967355280 date "2014-10-30" @default.
• W1967355280 modified "2023-09-25" @default.
• W1967355280 title "Mechanistic Details of the Membrane Perforation and Passive Translocation of TAT Peptides" @default.
• W1967355280 cites W1967217672 @default.
• W1967355280 cites W1970004609 @default.
• W1967355280 cites W1970025468 @default.
• W1967355280 cites W1978165514 @default.
• W1967355280 cites W1978600513 @default.
• W1967355280 cites W1984877105 @default.
• W1967355280 cites W1986519330 @default.
• W1967355280 cites W1986609553 @default.
• W1967355280 cites W1987411627 @default.
• W1967355280 cites W1988180248 @default.
• W1967355280 cites W1995247662 @default.
• W1967355280 cites W1996685148 @default.
• W1967355280 cites W2001582257 @default.
• W1967355280 cites W2005688834 @default.
• W1967355280 cites W2008813620 @default.
• W1967355280 cites W2009309713 @default.
• W1967355280 cites W2011923320 @default.
• W1967355280 cites W2014001405 @default.
• W1967355280 cites W2018013330 @default.
• W1967355280 cites W2020015356 @default.
• W1967355280 cites W2028138612 @default.
• W1967355280 cites W2029956296 @default.
• W1967355280 cites W2030081332 @default.
• W1967355280 cites W2037305018 @default.
• W1967355280 cites W2040223520 @default.
• W1967355280 cites W2042143995 @default.
• W1967355280 cites W2044015705 @default.
• W1967355280 cites W2046704370 @default.
• W1967355280 cites W2055471399 @default.
• W1967355280 cites W2056263305 @default.
• W1967355280 cites W2076859770 @default.
• W1967355280 cites W2079335891 @default.
• W1967355280 cites W2082899244 @default.
• W1967355280 cites W2088119617 @default.
• W1967355280 cites W2090587927 @default.
• W1967355280 cites W2097499636 @default.
• W1967355280 cites W2100619725 @default.
• W1967355280 cites W2102125805 @default.
• W1967355280 cites W2105668301 @default.
• W1967355280 cites W2112750469 @default.
• W1967355280 cites W2113079878 @default.
• W1967355280 cites W2118578511 @default.
• W1967355280 cites W2124016062 @default.
• W1967355280 cites W2126966136 @default.
• W1967355280 cites W2128873134 @default.
• W1967355280 cites W2135986253 @default.
• W1967355280 cites W2157327967 @default.
• W1967355280 cites W2172695216 @default.
• W1967355280 cites W2334376416 @default.
• W1967355280 cites W2599199563 @default.
• W1967355280 cites W4239028853 @default.
• W1967355280 cites W4246281388 @default.
• W1967355280 doi "https://doi.org/10.1002/cplu.201402209" @default.
• W1967355280 hasPublicationYear "2014" @default.
• W1967355280 type Work @default.
• W1967355280 sameAs 1967355280 @default.
• W1967355280 citedByCount "10" @default.
• W1967355280 countsByYear W19673552802015 @default.
• W1967355280 countsByYear W19673552802016 @default.
• W1967355280 countsByYear W19673552802017 @default.
• W1967355280 countsByYear W19673552802018 @default.
• W1967355280 countsByYear W19673552802021 @default.
• W1967355280 countsByYear W19673552802022 @default.
• W1967355280 crossrefType "journal-article" @default.
• W1967355280 hasAuthorship W1967355280A5026737180 @default.
• W1967355280 hasAuthorship W1967355280A5028954833 @default.
• W1967355280 hasAuthorship W1967355280A5036482071 @default.
• W1967355280 hasAuthorship W1967355280A5037644100 @default.
• W1967355280 hasAuthorship W1967355280A5040934489 @default.
• W1967355280 hasAuthorship W1967355280A5043580508 @default.
• W1967355280 hasAuthorship W1967355280A5046268649 @default.
• W1967355280 hasAuthorship W1967355280A5050672687 @default.
• W1967355280 hasAuthorship W1967355280A5055403368 @default.
• W1967355280 hasBestOaLocation W19673552802 @default.
• W1967355280 hasConcept C12554922 @default.
• W1967355280 hasConcept C185592680 @default.
• W1967355280 hasConcept C2776929087 @default.
• W1967355280 hasConcept C2778001312 @default.
• W1967355280 hasConcept C2779281246 @default.
• W1967355280 hasConcept C41625074 @default.
• W1967355280 hasConcept C55493867 @default.
• W1967355280 hasConcept C86803240 @default.
• W1967355280 hasConceptScore W1967355280C12554922 @default.
• W1967355280 hasConceptScore W1967355280C185592680 @default.

• next