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- W1967360087 abstract "Lymph/plasma concentration ratios (R) were measured for Dextran-110 and for several plasma protein components resolved by disc electrophoresis or gel filtration of dog leg lymph before and after injection of histamine, bradykinin, serotonin (5-HT), or vasodilators into the paw. Most of the molecules studied were larger than can be transported by the hypothetical small pore system (radius 40 Å). Control R for plasma proteins showed a general decline with increasing molecular size. Transport could be accounted for equally well by ultrafiltration through a small number of large pores (r ≧ 1600Å) or by turnover of endothelial vesicles (internal radius 250 Å). Secondary deviations from a strict permeability-molecular size relation suggest that for proteins, permeability is decreased by negative charge. Dextran molecules are transported less readily than proteins of the same effective size. This cannot be attributed to charge, but may be due to differences in molecular configuration or to chemical interactions. Histamine or bradykinin (but not 5-HT or vasodilators) diminish the selectivity of the blood-lymph barrier with respect to molecular size. The effects of electrical charge are also diminished, as is the difference between Dextrans and proteins. These changes in permeability are due entirely to alteration of the capillary pathway for large molecule transport (large pores or vesicles). The data cannot readily be fitted to theoretical predictions for an increase in size or number of large pores, but can be accounted for by an increase in size and volume turnover of endothelial vesicles (cytopempsis)." @default.
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- W1967360087 date "1974-01-01" @default.
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- W1967360087 title "Effects of histamine and some other substances on molecular selectivity of the capillary wall to plasma proteins and dextran" @default.
- W1967360087 doi "https://doi.org/10.1016/0026-2862(74)90035-1" @default.
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