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- W1967371216 abstract "The screening of microbial natural products continues to represent an important route to the discovery of novel chemicals for development of new therapeutic agents. The aim of this work was to develop an efficient method for the detection of immunosuppressive compounds produced by soil actinomycetes . Mutant strain of Saccharomyces cerevisiae , named FAV20, sensitive to FK506 was constructed by disrupting VMA22 gene using the selectable marker kan MX4 which allowed detection of integration events. Actinomycetes were isolated from different soil samples and in a newly developed test with S. cerevisiae FAV20, six strains have been identified that produce bioactive compounds with the same mechanism of action as FK506. S. cerevisiae FAV20 can be easily used as a test strain in drug screening programs based on inhibition of the calcineurin phosphatase dependent signaling pathway in the cell." @default.
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- W1967371216 date "2005-04-01" @default.
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- W1967371216 title "Construction of Saccharomyces cerevisiae strain FAV20 useful in detection of immunosuppressants produced by soil actinomycetes" @default.
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- W1967371216 doi "https://doi.org/10.1016/j.mimet.2004.11.007" @default.
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