FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967371432> ?p ?o ?g. }

• W1967371432 endingPage "1457" @default.
• W1967371432 startingPage "1457" @default.
• W1967371432 abstract "To investigate the clinicopathologic characteristics and prognostic implications associated with loss of CDX2 expression in colorectal cancers (CRCs).We immunohistochemically evaluated CDX2 expression in 713 CRCs and paired our findings to clinicopathologic and molecular characteristics of each individual. Endpoints included cytokeratin 7 and CK20 expression, microsatellite instability, CpG island methylator phenotype, and KRAS and BRAF mutation statuses. Univariate and multivariate survival analysis was performed to reveal the prognostic value of CDX2 downregulation.CDX2 expression was lost in 42 (5.9%) patients. Moreover, loss of CDX2 expression was associated with proximal location, infiltrative growth, advanced T, N, M and overall stage. On microscopic examination, loss of CDX2 expression was associated with poor differentiation, increased number of tumor-infiltrating lymphocytes, luminal serration and mucin production. Loss of CDX2 expression was also associated with increased CK7 expression, decreased CK20 expression, CpG island methylator phenotype, microsatellite instability and BRAF mutation. In a univariate survival analysis, patients with loss of CDX2 expression showed worse overall survival (P < 0.001) and progression-free survival (P < 0.001). In a multivariate survival analysis, loss of CDX2 expression was an independent poor prognostic factor of overall survival [hazard ratio (HR) = 1.72, 95%CI: 1.04-2.85, P = 0.034] and progression-free survival (HR = 1.94, 95%CI: 1.22-3.07, P = 0.005).Loss of CDX2 expression is associated with aggressive clinical behavior and can be used as a prognostic marker in CRCs." @default.
• W1967371432 created "2016-06-24" @default.
• W1967371432 creator A5009933828 @default.
• W1967371432 creator A5048050478 @default.
• W1967371432 creator A5056013655 @default.
• W1967371432 creator A5058012899 @default.
• W1967371432 creator A5084535090 @default.
• W1967371432 date "2015-01-01" @default.
• W1967371432 modified "2023-10-01" @default.
• W1967371432 title "Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients" @default.
• W1967371432 cites W1519949493 @default.
• W1967371432 cites W1778923464 @default.
• W1967371432 cites W1959756009 @default.
• W1967371432 cites W1966145948 @default.
• W1967371432 cites W1976392356 @default.
• W1967371432 cites W1985953899 @default.
• W1967371432 cites W1987648433 @default.
• W1967371432 cites W1988883407 @default.
• W1967371432 cites W1990978338 @default.
• W1967371432 cites W1998340711 @default.
• W1967371432 cites W2002512097 @default.
• W1967371432 cites W2008273825 @default.
• W1967371432 cites W2008889615 @default.
• W1967371432 cites W2012231091 @default.
• W1967371432 cites W2013306879 @default.
• W1967371432 cites W2025370613 @default.
• W1967371432 cites W2032897100 @default.
• W1967371432 cites W2033279626 @default.
• W1967371432 cites W2038188490 @default.
• W1967371432 cites W2041963100 @default.
• W1967371432 cites W2052671006 @default.
• W1967371432 cites W2053731598 @default.
• W1967371432 cites W2054022354 @default.
• W1967371432 cites W2056163452 @default.
• W1967371432 cites W2064854706 @default.
• W1967371432 cites W2067438558 @default.
• W1967371432 cites W2071979876 @default.
• W1967371432 cites W2079860844 @default.
• W1967371432 cites W2088579097 @default.
• W1967371432 cites W2094175630 @default.
• W1967371432 cites W2097018007 @default.
• W1967371432 cites W2099556709 @default.
• W1967371432 cites W2101402853 @default.
• W1967371432 cites W2109453679 @default.
• W1967371432 cites W2113284270 @default.
• W1967371432 cites W2117424291 @default.
• W1967371432 cites W2128062921 @default.
• W1967371432 cites W2133578225 @default.
• W1967371432 cites W2137195081 @default.
• W1967371432 cites W2143537730 @default.
• W1967371432 cites W2144172360 @default.
• W1967371432 cites W2144768795 @default.
• W1967371432 cites W2145607651 @default.
• W1967371432 cites W2151715235 @default.
• W1967371432 cites W2153555657 @default.
• W1967371432 cites W2159118517 @default.
• W1967371432 cites W2165302354 @default.
• W1967371432 cites W2166125579 @default.
• W1967371432 cites W2262414037 @default.
• W1967371432 cites W2915373011 @default.
• W1967371432 cites W57919084 @default.
• W1967371432 doi "https://doi.org/10.3748/wjg.v21.i5.1457" @default.
• W1967371432 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4316088" @default.
• W1967371432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25663765" @default.
• W1967371432 hasPublicationYear "2015" @default.
• W1967371432 type Work @default.
• W1967371432 sameAs 1967371432 @default.
• W1967371432 citedByCount "89" @default.
• W1967371432 countsByYear W19673714322015 @default.
• W1967371432 countsByYear W19673714322016 @default.
• W1967371432 countsByYear W19673714322017 @default.
• W1967371432 countsByYear W19673714322018 @default.
• W1967371432 countsByYear W19673714322019 @default.
• W1967371432 countsByYear W19673714322020 @default.
• W1967371432 countsByYear W19673714322021 @default.
• W1967371432 countsByYear W19673714322022 @default.
• W1967371432 countsByYear W19673714322023 @default.
• W1967371432 crossrefType "journal-article" @default.
• W1967371432 hasAuthorship W1967371432A5009933828 @default.
• W1967371432 hasAuthorship W1967371432A5048050478 @default.
• W1967371432 hasAuthorship W1967371432A5056013655 @default.
• W1967371432 hasAuthorship W1967371432A5058012899 @default.
• W1967371432 hasAuthorship W1967371432A5084535090 @default.
• W1967371432 hasBestOaLocation W19673714321 @default.
• W1967371432 hasConcept C104317684 @default.
• W1967371432 hasConcept C10515644 @default.
• W1967371432 hasConcept C121587040 @default.
• W1967371432 hasConcept C121608353 @default.
• W1967371432 hasConcept C126322002 @default.
• W1967371432 hasConcept C131364181 @default.
• W1967371432 hasConcept C142724271 @default.
• W1967371432 hasConcept C143998085 @default.
• W1967371432 hasConcept C144301174 @default.
• W1967371432 hasConcept C150194340 @default.
• W1967371432 hasConcept C180754005 @default.
• W1967371432 hasConcept C207103383 @default.
• W1967371432 hasConcept C2779767149 @default.
• W1967371432 hasConcept C38180746 @default.

• next