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- W1967376170 abstract "The pim-1 oncogene is regulated by hematopoietic cytokine receptors, encodes a serine/threonine protein kinase, and cooperates with c-myc in lymphoid cell transformation. Using a yeast two-hybrid screen, we found that Pim-1 protein binds to p100, a transcriptional coactivator that interacts with the c-Myb transcription factor. Pim-1 phosphorylated p100 in vitro, formed a stable complex with p100 in animal cells, and functioned downstream of Ras to stimulate c-Myb transcriptional activity in a p100-dependent manner. Thus, Pim-1 and p100 appear to be components of a novel signal transduction pathway affecting c-Myb activity, linking all three to the cytokine-regulated control of hematopoietic cell growth, differentiation, and apoptosis." @default.
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- W1967376170 date "1998-10-01" @default.
- W1967376170 modified "2023-10-18" @default.
- W1967376170 title "Pim-1 Kinase and p100 Cooperate to Enhance c-Myb Activity" @default.
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- W1967376170 doi "https://doi.org/10.1016/s1097-2765(00)80141-0" @default.
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