Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967376415> ?p ?o ?g. }
- W1967376415 endingPage "488" @default.
- W1967376415 startingPage "478" @default.
- W1967376415 abstract "Respiratory infections in early life can lead to chronic respiratory disease. Chlamydia infections are common causes of respiratory disease, particularly pneumonia in neonates, and are linked to permanent reductions in pulmonary function and the induction of asthma. However, the immune responses that protect against early-life infection and the mechanisms that lead to chronic lung disease are incompletely understood. Here we identify novel roles for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in promoting Chlamydia respiratory infection-induced pathology in early life, and subsequent chronic lung disease. By infecting TRAIL-deficient neonatal mice and using neutralizing antibodies against this factor and its receptors in wild-type mice, we demonstrate that TRAIL is critical in promoting infection-induced histopathology, inflammation, and mucus hypersecretion, as well as subsequent alveolar enlargement and impaired lung function. This suggests that therapeutic agents that target TRAIL or its receptors may be effective treatments for early-life respiratory infections and associated chronic lung disease." @default.
- W1967376415 created "2016-06-24" @default.
- W1967376415 creator A5009041563 @default.
- W1967376415 creator A5009157699 @default.
- W1967376415 creator A5013134399 @default.
- W1967376415 creator A5015543605 @default.
- W1967376415 creator A5038695159 @default.
- W1967376415 creator A5040579435 @default.
- W1967376415 creator A5043300180 @default.
- W1967376415 creator A5049999305 @default.
- W1967376415 creator A5056502030 @default.
- W1967376415 creator A5070494006 @default.
- W1967376415 creator A5076048446 @default.
- W1967376415 date "2014-05-01" @default.
- W1967376415 modified "2023-10-01" @default.
- W1967376415 title "Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease" @default.
- W1967376415 cites W1586150156 @default.
- W1967376415 cites W1593235986 @default.
- W1967376415 cites W1815198958 @default.
- W1967376415 cites W1931862786 @default.
- W1967376415 cites W1973691444 @default.
- W1967376415 cites W1974389984 @default.
- W1967376415 cites W1980919524 @default.
- W1967376415 cites W1981608517 @default.
- W1967376415 cites W1989131752 @default.
- W1967376415 cites W1990886400 @default.
- W1967376415 cites W1991991100 @default.
- W1967376415 cites W1994397835 @default.
- W1967376415 cites W2001178427 @default.
- W1967376415 cites W2002980923 @default.
- W1967376415 cites W2003176984 @default.
- W1967376415 cites W2005589576 @default.
- W1967376415 cites W2005951118 @default.
- W1967376415 cites W2013109381 @default.
- W1967376415 cites W2016727408 @default.
- W1967376415 cites W2035516871 @default.
- W1967376415 cites W2036897993 @default.
- W1967376415 cites W2038760548 @default.
- W1967376415 cites W2061546617 @default.
- W1967376415 cites W2062774911 @default.
- W1967376415 cites W2063379758 @default.
- W1967376415 cites W2068054150 @default.
- W1967376415 cites W2069501078 @default.
- W1967376415 cites W2077793109 @default.
- W1967376415 cites W2082848636 @default.
- W1967376415 cites W2089207400 @default.
- W1967376415 cites W2089476060 @default.
- W1967376415 cites W2092508425 @default.
- W1967376415 cites W2095999248 @default.
- W1967376415 cites W2103585613 @default.
- W1967376415 cites W2105053798 @default.
- W1967376415 cites W2109510813 @default.
- W1967376415 cites W2110084692 @default.
- W1967376415 cites W2113505777 @default.
- W1967376415 cites W2117563914 @default.
- W1967376415 cites W2130988210 @default.
- W1967376415 cites W2137741745 @default.
- W1967376415 cites W2139239087 @default.
- W1967376415 cites W2139759276 @default.
- W1967376415 cites W2141611143 @default.
- W1967376415 cites W2142182232 @default.
- W1967376415 cites W2144944593 @default.
- W1967376415 cites W2156522249 @default.
- W1967376415 cites W2160925138 @default.
- W1967376415 cites W2161593731 @default.
- W1967376415 cites W2161888789 @default.
- W1967376415 cites W2164473032 @default.
- W1967376415 cites W2166860906 @default.
- W1967376415 doi "https://doi.org/10.1038/mi.2013.65" @default.
- W1967376415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24045576" @default.
- W1967376415 hasPublicationYear "2014" @default.
- W1967376415 type Work @default.
- W1967376415 sameAs 1967376415 @default.
- W1967376415 citedByCount "45" @default.
- W1967376415 countsByYear W19673764152014 @default.
- W1967376415 countsByYear W19673764152015 @default.
- W1967376415 countsByYear W19673764152016 @default.
- W1967376415 countsByYear W19673764152017 @default.
- W1967376415 countsByYear W19673764152018 @default.
- W1967376415 countsByYear W19673764152019 @default.
- W1967376415 countsByYear W19673764152020 @default.
- W1967376415 countsByYear W19673764152021 @default.
- W1967376415 countsByYear W19673764152022 @default.
- W1967376415 countsByYear W19673764152023 @default.
- W1967376415 crossrefType "journal-article" @default.
- W1967376415 hasAuthorship W1967376415A5009041563 @default.
- W1967376415 hasAuthorship W1967376415A5009157699 @default.
- W1967376415 hasAuthorship W1967376415A5013134399 @default.
- W1967376415 hasAuthorship W1967376415A5015543605 @default.
- W1967376415 hasAuthorship W1967376415A5038695159 @default.
- W1967376415 hasAuthorship W1967376415A5040579435 @default.
- W1967376415 hasAuthorship W1967376415A5043300180 @default.
- W1967376415 hasAuthorship W1967376415A5049999305 @default.
- W1967376415 hasAuthorship W1967376415A5056502030 @default.
- W1967376415 hasAuthorship W1967376415A5070494006 @default.
- W1967376415 hasAuthorship W1967376415A5076048446 @default.
- W1967376415 hasBestOaLocation W19673764151 @default.
- W1967376415 hasConcept C126322002 @default.