Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967376423> ?p ?o ?g. }
- W1967376423 endingPage "68" @default.
- W1967376423 startingPage "55" @default.
- W1967376423 abstract "Butyl benzyl phthalate (BBP) has been shown to be teratogenic. One mechanism contributing to the teratogenicity of several developmental toxicants, is chemical-induced changes in maternal zinc (Zn) metabolism which result in an increased synthesis of maternal liver metallothionein (Mt), and a subsequent reduction in Zn delivery to the conceptus. We investigated the effects of maternal BBP exposure on maternal-fetal Zn metabolism in Wistar rats. In study I, dams were gavaged with BBP (0, 250, 1000, 1500 or 2000 mg/kg) on gestation days (GD) 11 through 13, and killed on GD 20. Maternal toxicity was evident in the three highest dose groups. Embryo/fetal death and small pup weights and lengths were noted in the 2000 mg BBP/kg group. Fetuses in the 1500 and 2000 mg/kg groups were characterized by poor skeletal ossification, and a high frequency of cleft palate. Rib anomalies were observed in the three highest dose groups. Maternal liver Mt concentrations were only slightly elevated in the 1500 and 2000 mg/kg groups. In study II, dams treated as above, were gavaged with 65Zn and killed 18 h later. While the 2000 mg/kg group had high percentages of 65Zn in some maternal tissues, sequestration of 65Zn in maternal liver was not evident. Thus, BBP is not a strong inducer of Mt, and the teratogenicity of BBP does not appear to be due to alterations in maternal and/or embryonic Zn metabolism." @default.
- W1967376423 created "2016-06-24" @default.
- W1967376423 creator A5012820548 @default.
- W1967376423 creator A5014148583 @default.
- W1967376423 creator A5040251521 @default.
- W1967376423 creator A5043985150 @default.
- W1967376423 creator A5070051627 @default.
- W1967376423 creator A5081660505 @default.
- W1967376423 creator A5071977289 @default.
- W1967376423 date "2001-02-01" @default.
- W1967376423 modified "2023-09-25" @default.
- W1967376423 title "Effect of butyl benzyl phthalate on reproduction and zinc metabolism" @default.
- W1967376423 cites W1543669829 @default.
- W1967376423 cites W1572873372 @default.
- W1967376423 cites W1964770701 @default.
- W1967376423 cites W1970791809 @default.
- W1967376423 cites W1976274041 @default.
- W1967376423 cites W1979268276 @default.
- W1967376423 cites W1980532326 @default.
- W1967376423 cites W1985559618 @default.
- W1967376423 cites W2005721446 @default.
- W1967376423 cites W2006261800 @default.
- W1967376423 cites W2011258416 @default.
- W1967376423 cites W2021392024 @default.
- W1967376423 cites W2021583624 @default.
- W1967376423 cites W2023635770 @default.
- W1967376423 cites W2029932272 @default.
- W1967376423 cites W2035522662 @default.
- W1967376423 cites W2036466244 @default.
- W1967376423 cites W2038072799 @default.
- W1967376423 cites W2039609167 @default.
- W1967376423 cites W2043387905 @default.
- W1967376423 cites W2046952459 @default.
- W1967376423 cites W2047041872 @default.
- W1967376423 cites W2052385802 @default.
- W1967376423 cites W2054096613 @default.
- W1967376423 cites W2056917827 @default.
- W1967376423 cites W2058877449 @default.
- W1967376423 cites W2073960752 @default.
- W1967376423 cites W2077643027 @default.
- W1967376423 cites W2083767580 @default.
- W1967376423 cites W2088994822 @default.
- W1967376423 cites W2091354650 @default.
- W1967376423 cites W2093334173 @default.
- W1967376423 cites W2094544087 @default.
- W1967376423 cites W2613721625 @default.
- W1967376423 cites W4247905931 @default.
- W1967376423 doi "https://doi.org/10.1016/s0300-483x(00)00403-0" @default.
- W1967376423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11250055" @default.
- W1967376423 hasPublicationYear "2001" @default.
- W1967376423 type Work @default.
- W1967376423 sameAs 1967376423 @default.
- W1967376423 citedByCount "21" @default.
- W1967376423 countsByYear W19673764232012 @default.
- W1967376423 countsByYear W19673764232013 @default.
- W1967376423 countsByYear W19673764232015 @default.
- W1967376423 countsByYear W19673764232017 @default.
- W1967376423 countsByYear W19673764232022 @default.
- W1967376423 countsByYear W19673764232023 @default.
- W1967376423 crossrefType "journal-article" @default.
- W1967376423 hasAuthorship W1967376423A5012820548 @default.
- W1967376423 hasAuthorship W1967376423A5014148583 @default.
- W1967376423 hasAuthorship W1967376423A5040251521 @default.
- W1967376423 hasAuthorship W1967376423A5043985150 @default.
- W1967376423 hasAuthorship W1967376423A5070051627 @default.
- W1967376423 hasAuthorship W1967376423A5071977289 @default.
- W1967376423 hasAuthorship W1967376423A5081660505 @default.
- W1967376423 hasConcept C126322002 @default.
- W1967376423 hasConcept C134018914 @default.
- W1967376423 hasConcept C16685009 @default.
- W1967376423 hasConcept C172680121 @default.
- W1967376423 hasConcept C178790620 @default.
- W1967376423 hasConcept C179335377 @default.
- W1967376423 hasConcept C185592680 @default.
- W1967376423 hasConcept C196843134 @default.
- W1967376423 hasConcept C201614185 @default.
- W1967376423 hasConcept C20719415 @default.
- W1967376423 hasConcept C2779234561 @default.
- W1967376423 hasConcept C2781005124 @default.
- W1967376423 hasConcept C29730261 @default.
- W1967376423 hasConcept C32253518 @default.
- W1967376423 hasConcept C46973012 @default.
- W1967376423 hasConcept C535196362 @default.
- W1967376423 hasConcept C54355233 @default.
- W1967376423 hasConcept C62231903 @default.
- W1967376423 hasConcept C65290608 @default.
- W1967376423 hasConcept C71924100 @default.
- W1967376423 hasConcept C86803240 @default.
- W1967376423 hasConcept C95444343 @default.
- W1967376423 hasConceptScore W1967376423C126322002 @default.
- W1967376423 hasConceptScore W1967376423C134018914 @default.
- W1967376423 hasConceptScore W1967376423C16685009 @default.
- W1967376423 hasConceptScore W1967376423C172680121 @default.
- W1967376423 hasConceptScore W1967376423C178790620 @default.
- W1967376423 hasConceptScore W1967376423C179335377 @default.
- W1967376423 hasConceptScore W1967376423C185592680 @default.
- W1967376423 hasConceptScore W1967376423C196843134 @default.
- W1967376423 hasConceptScore W1967376423C201614185 @default.