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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967401188> ?p ?o ?g. }

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• W1967401188 abstract "Estrogen responsive breast cancer cell lines have been extensively studied to characterize transcriptional patterns in hormone-responsive tumors. Nevertheless, due to current technological limitations, genome-wide studies have typically been limited to population averaged data. Here we obtain, for the first time, a characterization at the single-cell level of the states and expression signatures of a hormone-starved MCF-7 cell system responding to estrogen. To do so, we employ a recently proposed model that allows for dissecting single-cell states from time-course microarray data. We show that within 32 hours following stimulation, MCF-7 cells traverse, most likely, six states, with a faster early response followed by a progressive deceleration. We also derive the genome-wide transcriptional profiles of such single-cell states and their functional characterization. Our results support a scenario where estrogen promotes cell cycle progression by controlling multiple, sequential regulatory steps, whose single-cell events are here identified." @default.
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• W1967401188 date "2014-02-25" @default.
• W1967401188 modified "2023-10-06" @default.
• W1967401188 title "Single-Cell States in the Estrogen Response of Breast Cancer Cell Lines" @default.
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• W1967401188 doi "https://doi.org/10.1371/journal.pone.0088485" @default.
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