FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967402893> ?p ?o ?g. }

• W1967402893 endingPage "14" @default.
• W1967402893 startingPage "14" @default.
• W1967402893 abstract "Much attention has been recently focused on the role of cancer stem cells (CSCs) in the initiation and progression of solid malignancies. Since CSCs are able to proliferate and self-renew extensively due to their ability to express anti-apoptotic and drug resistant proteins, thus sustaining tumor growth. Therefore, the strategy to eradicate CSCs might have significant clinical implications. The objectives of this study were to examine the molecular mechanisms by which epigallocathechin gallate (EGCG) inhibits stem cell characteristics of prostate CSCs, and synergizes with quercetin, a major polyphenol and flavonoid commonly detected in many fruits and vegetables.Our data indicate that human prostate cancer cell lines contain a small population of CD44+CD133+ cancer stem cells and their self-renewal capacity is inhibited by EGCG. Furthermore, EGCG inhibits the self-renewal capacity of CD44+alpha2beta1+CD133+ CSCs isolated from human primary prostate tumors, as measured by spheroid formation in suspension. EGCG induces apoptosis by activating capase-3/7 and inhibiting the expression of Bcl-2, survivin and XIAP in CSCs. Furthermore, EGCG inhibits epithelial-mesenchymal transition by inhibiting the expression of vimentin, slug, snail and nuclear beta-catenin, and the activity of LEF-1/TCF responsive reporter, and also retards CSC's migration and invasion, suggesting the blockade of signaling involved in early metastasis. Interestingly, quercetin synergizes with EGCG in inhibiting the self-renewal properties of prostate CSCs, inducing apoptosis, and blocking CSC's migration and invasion. These data suggest that EGCG either alone or in combination with quercetin can eliminate cancer stem cell-characteristics.Since carcinogenesis is a complex process, combination of bioactive dietary agents with complementary activities will be beneficial for prostate cancer prevention and/ortreatment." @default.
• W1967402893 created "2016-06-24" @default.
• W1967402893 creator A5000328002 @default.
• W1967402893 creator A5000344564 @default.
• W1967402893 creator A5014128022 @default.
• W1967402893 creator A5016488931 @default.
• W1967402893 creator A5036931156 @default.
• W1967402893 creator A5038606074 @default.
• W1967402893 date "2010-08-18" @default.
• W1967402893 modified "2023-10-10" @default.
• W1967402893 title "The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition" @default.
• W1967402893 cites W1017635152 @default.
• W1967402893 cites W1569235484 @default.
• W1967402893 cites W16823839 @default.
• W1967402893 cites W183694329 @default.
• W1967402893 cites W1838354729 @default.
• W1967402893 cites W1917820844 @default.
• W1967402893 cites W1964081206 @default.
• W1967402893 cites W1965568527 @default.
• W1967402893 cites W1966115488 @default.
• W1967402893 cites W1967245224 @default.
• W1967402893 cites W1967656020 @default.
• W1967402893 cites W1968332094 @default.
• W1967402893 cites W1975587250 @default.
• W1967402893 cites W1978787271 @default.
• W1967402893 cites W1981705266 @default.
• W1967402893 cites W1982580620 @default.
• W1967402893 cites W1984641834 @default.
• W1967402893 cites W1984833201 @default.
• W1967402893 cites W1985683994 @default.
• W1967402893 cites W1985927164 @default.
• W1967402893 cites W1987317889 @default.
• W1967402893 cites W1987874332 @default.
• W1967402893 cites W1991636099 @default.
• W1967402893 cites W1991904087 @default.
• W1967402893 cites W1992566095 @default.
• W1967402893 cites W1996318057 @default.
• W1967402893 cites W1997203401 @default.
• W1967402893 cites W1999797961 @default.
• W1967402893 cites W2001544973 @default.
• W1967402893 cites W2002427864 @default.
• W1967402893 cites W2002658591 @default.
• W1967402893 cites W2002738876 @default.
• W1967402893 cites W2004624656 @default.
• W1967402893 cites W2005240156 @default.
• W1967402893 cites W2006049488 @default.
• W1967402893 cites W2007770152 @default.
• W1967402893 cites W2009904848 @default.
• W1967402893 cites W2010048036 @default.
• W1967402893 cites W2010606767 @default.
• W1967402893 cites W2010608530 @default.
• W1967402893 cites W2012619882 @default.
• W1967402893 cites W2014128254 @default.
• W1967402893 cites W2015831734 @default.
• W1967402893 cites W2015967888 @default.
• W1967402893 cites W2016823780 @default.
• W1967402893 cites W2017950977 @default.
• W1967402893 cites W2019264784 @default.
• W1967402893 cites W2020711428 @default.
• W1967402893 cites W2020782011 @default.
• W1967402893 cites W2023316892 @default.
• W1967402893 cites W2023427658 @default.
• W1967402893 cites W2025964103 @default.
• W1967402893 cites W2026587086 @default.
• W1967402893 cites W2028593825 @default.
• W1967402893 cites W2029231546 @default.
• W1967402893 cites W2030074887 @default.
• W1967402893 cites W2030326590 @default.
• W1967402893 cites W2032729098 @default.
• W1967402893 cites W2032845267 @default.
• W1967402893 cites W2037016917 @default.
• W1967402893 cites W2038873665 @default.
• W1967402893 cites W2039414265 @default.
• W1967402893 cites W2039915589 @default.
• W1967402893 cites W2040511639 @default.
• W1967402893 cites W2045477445 @default.
• W1967402893 cites W2046788126 @default.
• W1967402893 cites W2049522324 @default.
• W1967402893 cites W2050776828 @default.
• W1967402893 cites W2051065236 @default.
• W1967402893 cites W2051204314 @default.
• W1967402893 cites W2051683846 @default.
• W1967402893 cites W2052339653 @default.
• W1967402893 cites W2053912747 @default.
• W1967402893 cites W2054054828 @default.
• W1967402893 cites W2055130200 @default.
• W1967402893 cites W2055780054 @default.
• W1967402893 cites W2056992430 @default.
• W1967402893 cites W2058331499 @default.
• W1967402893 cites W2058831515 @default.
• W1967402893 cites W2059022111 @default.
• W1967402893 cites W2062069198 @default.
• W1967402893 cites W2063382430 @default.
• W1967402893 cites W2066017833 @default.
• W1967402893 cites W2067485085 @default.
• W1967402893 cites W2069381736 @default.
• W1967402893 cites W2072292536 @default.
• W1967402893 cites W2075245880 @default.

• next