Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967459325> ?p ?o ?g. }
- W1967459325 endingPage "543" @default.
- W1967459325 startingPage "535" @default.
- W1967459325 abstract "Purpose of review Colistin is a 50-year-old antibiotic that is being used increasingly as a ‘last-line’ therapy to treat infections caused by multidrug-resistant Gram-negative bacteria, when essentially no other options are available. Despite its age, or because of its age, there has been a dearth of knowledge on its pharmacological and microbiological properties. This review focuses on recent studies aimed at optimizing the clinical use of this old antibiotic. Recent findings A number of factors, including the diversity in the pharmaceutical products available, have hindered the optimal use of colistin. Recent advances in understanding of the pharmacokinetics and pharmacodynamics of colistin, and the emerging knowledge on the relationship between the pharmacokinetics and pharmacodynamics, provide a solid base for optimization of dosage regimens. The potential for nephrotoxicity has been a lingering concern, but recent studies provide useful new information on the incidence, severity and reversibility of this adverse effect. Recent approaches to the use of other antibiotics in combination with colistin hold promise for increased antibacterial efficacy with less potential for emergence of resistance. Summary Because few, if any, new antibiotics with activity against multidrug-resistant Gram-negative bacteria will be available within the next several years, it is essential that colistin is used in ways that maximize its antibacterial efficacy and minimize toxicity and development of resistance. Recent developments have improved use of colistin in the 21st century." @default.
- W1967459325 created "2016-06-24" @default.
- W1967459325 creator A5027524219 @default.
- W1967459325 creator A5073046394 @default.
- W1967459325 date "2009-12-01" @default.
- W1967459325 modified "2023-10-17" @default.
- W1967459325 title "Colistin in the 21st century" @default.
- W1967459325 cites W1582342805 @default.
- W1967459325 cites W1602597014 @default.
- W1967459325 cites W1818889778 @default.
- W1967459325 cites W1951214294 @default.
- W1967459325 cites W1964141703 @default.
- W1967459325 cites W1965625200 @default.
- W1967459325 cites W1971252925 @default.
- W1967459325 cites W1973063953 @default.
- W1967459325 cites W1981142566 @default.
- W1967459325 cites W1985567596 @default.
- W1967459325 cites W1990526767 @default.
- W1967459325 cites W1992256680 @default.
- W1967459325 cites W1993853340 @default.
- W1967459325 cites W2001193279 @default.
- W1967459325 cites W2002423253 @default.
- W1967459325 cites W2003690191 @default.
- W1967459325 cites W2009912574 @default.
- W1967459325 cites W2021190135 @default.
- W1967459325 cites W2023469834 @default.
- W1967459325 cites W2023995330 @default.
- W1967459325 cites W2027986692 @default.
- W1967459325 cites W2029452886 @default.
- W1967459325 cites W2030379064 @default.
- W1967459325 cites W2053881022 @default.
- W1967459325 cites W2054435999 @default.
- W1967459325 cites W2063448964 @default.
- W1967459325 cites W2063508616 @default.
- W1967459325 cites W2064063323 @default.
- W1967459325 cites W2068342062 @default.
- W1967459325 cites W2070409152 @default.
- W1967459325 cites W2072941455 @default.
- W1967459325 cites W2081836275 @default.
- W1967459325 cites W2089666483 @default.
- W1967459325 cites W2090664858 @default.
- W1967459325 cites W2090940640 @default.
- W1967459325 cites W2091513339 @default.
- W1967459325 cites W2097700470 @default.
- W1967459325 cites W2098161344 @default.
- W1967459325 cites W2100619231 @default.
- W1967459325 cites W2100827124 @default.
- W1967459325 cites W2101273146 @default.
- W1967459325 cites W2104766341 @default.
- W1967459325 cites W2105915947 @default.
- W1967459325 cites W2114472139 @default.
- W1967459325 cites W2115096104 @default.
- W1967459325 cites W2115255709 @default.
- W1967459325 cites W2117795567 @default.
- W1967459325 cites W2117992352 @default.
- W1967459325 cites W2118734761 @default.
- W1967459325 cites W2119596752 @default.
- W1967459325 cites W2119670123 @default.
- W1967459325 cites W2120266293 @default.
- W1967459325 cites W2124381039 @default.
- W1967459325 cites W2124512516 @default.
- W1967459325 cites W2126504345 @default.
- W1967459325 cites W2128630890 @default.
- W1967459325 cites W2129148967 @default.
- W1967459325 cites W2131170758 @default.
- W1967459325 cites W2134747733 @default.
- W1967459325 cites W2138761472 @default.
- W1967459325 cites W2142188564 @default.
- W1967459325 cites W2144767644 @default.
- W1967459325 cites W2144940962 @default.
- W1967459325 cites W2148474643 @default.
- W1967459325 cites W2149483355 @default.
- W1967459325 cites W2149884385 @default.
- W1967459325 cites W2151999391 @default.
- W1967459325 cites W2153008687 @default.
- W1967459325 cites W2154234926 @default.
- W1967459325 cites W2154601452 @default.
- W1967459325 cites W2155869496 @default.
- W1967459325 cites W2156671335 @default.
- W1967459325 cites W2161229311 @default.
- W1967459325 cites W2162661622 @default.
- W1967459325 cites W2162745520 @default.
- W1967459325 cites W2163732007 @default.
- W1967459325 cites W2164032940 @default.
- W1967459325 cites W2164292002 @default.
- W1967459325 cites W2166348498 @default.
- W1967459325 cites W2168064490 @default.
- W1967459325 cites W2170395771 @default.
- W1967459325 cites W2171214880 @default.
- W1967459325 cites W2171421171 @default.
- W1967459325 cites W2171857175 @default.
- W1967459325 cites W2172054438 @default.
- W1967459325 cites W4211056710 @default.
- W1967459325 cites W4255507877 @default.
- W1967459325 doi "https://doi.org/10.1097/qco.0b013e328332e672" @default.
- W1967459325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2869076" @default.
- W1967459325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19797945" @default.
- W1967459325 hasPublicationYear "2009" @default.