FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967473008> ?p ?o ?g. }

• W1967473008 endingPage "1407" @default.
• W1967473008 startingPage "1401" @default.
• W1967473008 abstract "In this work we have compared the pattern of DNA fragmentation (in the size range 1–5700 kbp) induced in human fibroblasts by γ-rays with that induced by Fe ions with an energy of 115 MeV/u; Fe ions are considered of biological significance for radiation protection issues during long term astronauts’ travels. The study has taken into account the comparison of the experimental fragmentation spectra, their analysis performed through the implementation of a phenomenological model, and Monte Carlo simulations performed with the PARTRAC code. The phenomenological method characterizes in an approximate but simple way the nonrandom nature of the experimental fragment distribution caused by high LET radiation; it has the advantage to take into account in a detailed way the background fragmentation. The PARTRAC simulations, on the other hand, thanks to the accurate representation of the chromatin geometry and of the physical and physico-chemical processes associated with the energy deposition by radiation, offer the possibility to compute the spectra and to compare them with the experimental data. We found a satisfactory agreement between the experimental data and the results obtained with PARTRAC, recently upgraded with the implementation of ions heavier than alpha particles; this agreement represents a first validation of the code. A relevant result is represented by the very high number of fragments that, according to the Monte Carlo simulations, are produced by iron ions in the size range <1 kbp: half of the total number of radiation induced fragments is given by fragments in this size range. This is consistent with another important result, i.e., the very high DSB correlation that is found through the GBS model in the lower part of the experimental size range (1–9 kbp) for iron ions. The consequence of this large production of fragments smaller than 1 kbp, undetected experimentally, is the large difference between the experimental and theoretical values of the RBE for DSB production, given respectively by 1.34 and 2.39." @default.
• W1967473008 created "2016-06-24" @default.
• W1967473008 creator A5002041197 @default.
• W1967473008 creator A5017347937 @default.
• W1967473008 creator A5046499549 @default.
• W1967473008 creator A5052730302 @default.
• W1967473008 creator A5062208008 @default.
• W1967473008 creator A5062267872 @default.
• W1967473008 creator A5063682204 @default.
• W1967473008 creator A5082590563 @default.
• W1967473008 creator A5087784315 @default.
• W1967473008 date "2007-01-01" @default.
• W1967473008 modified "2023-10-16" @default.
• W1967473008 title "Modeling of DNA fragmentation induced in human fibroblasts by 56Fe ions" @default.
• W1967473008 cites W1963913196 @default.
• W1967473008 cites W1967154055 @default.
• W1967473008 cites W2002865233 @default.
• W1967473008 cites W2019963243 @default.
• W1967473008 cites W2022289931 @default.
• W1967473008 cites W2037755625 @default.
• W1967473008 cites W2053487277 @default.
• W1967473008 cites W2057795858 @default.
• W1967473008 cites W2062375412 @default.
• W1967473008 cites W2062728251 @default.
• W1967473008 cites W2063966833 @default.
• W1967473008 cites W2068386363 @default.
• W1967473008 cites W2084273927 @default.
• W1967473008 cites W2090002227 @default.
• W1967473008 cites W2092822342 @default.
• W1967473008 cites W2096545136 @default.
• W1967473008 cites W2100725360 @default.
• W1967473008 cites W2101613112 @default.
• W1967473008 cites W2105648889 @default.
• W1967473008 cites W2108934834 @default.
• W1967473008 cites W2125129609 @default.
• W1967473008 cites W2136647418 @default.
• W1967473008 cites W2176001433 @default.
• W1967473008 cites W2180487778 @default.
• W1967473008 cites W2188489292 @default.
• W1967473008 cites W2316709185 @default.
• W1967473008 doi "https://doi.org/10.1016/j.asr.2007.05.078" @default.
• W1967473008 hasPublicationYear "2007" @default.
• W1967473008 type Work @default.
• W1967473008 sameAs 1967473008 @default.
• W1967473008 citedByCount "10" @default.
• W1967473008 countsByYear W19674730082013 @default.
• W1967473008 countsByYear W19674730082014 @default.
• W1967473008 countsByYear W19674730082015 @default.
• W1967473008 crossrefType "journal-article" @default.
• W1967473008 hasAuthorship W1967473008A5002041197 @default.
• W1967473008 hasAuthorship W1967473008A5017347937 @default.
• W1967473008 hasAuthorship W1967473008A5046499549 @default.
• W1967473008 hasAuthorship W1967473008A5052730302 @default.
• W1967473008 hasAuthorship W1967473008A5062208008 @default.
• W1967473008 hasAuthorship W1967473008A5062267872 @default.
• W1967473008 hasAuthorship W1967473008A5063682204 @default.
• W1967473008 hasAuthorship W1967473008A5082590563 @default.
• W1967473008 hasAuthorship W1967473008A5087784315 @default.
• W1967473008 hasConcept C105795698 @default.
• W1967473008 hasConcept C121332964 @default.
• W1967473008 hasConcept C1276947 @default.
• W1967473008 hasConcept C145148216 @default.
• W1967473008 hasConcept C153385146 @default.
• W1967473008 hasConcept C159985019 @default.
• W1967473008 hasConcept C184779094 @default.
• W1967473008 hasConcept C185544564 @default.
• W1967473008 hasConcept C18903297 @default.
• W1967473008 hasConcept C191015642 @default.
• W1967473008 hasConcept C192562407 @default.
• W1967473008 hasConcept C19499675 @default.
• W1967473008 hasConcept C204323151 @default.
• W1967473008 hasConcept C30475298 @default.
• W1967473008 hasConcept C33923547 @default.
• W1967473008 hasConcept C4839761 @default.
• W1967473008 hasConcept C62520636 @default.
• W1967473008 hasConcept C86803240 @default.
• W1967473008 hasConceptScore W1967473008C105795698 @default.
• W1967473008 hasConceptScore W1967473008C121332964 @default.
• W1967473008 hasConceptScore W1967473008C1276947 @default.
• W1967473008 hasConceptScore W1967473008C145148216 @default.
• W1967473008 hasConceptScore W1967473008C153385146 @default.
• W1967473008 hasConceptScore W1967473008C159985019 @default.
• W1967473008 hasConceptScore W1967473008C184779094 @default.
• W1967473008 hasConceptScore W1967473008C185544564 @default.
• W1967473008 hasConceptScore W1967473008C18903297 @default.
• W1967473008 hasConceptScore W1967473008C191015642 @default.
• W1967473008 hasConceptScore W1967473008C192562407 @default.
• W1967473008 hasConceptScore W1967473008C19499675 @default.
• W1967473008 hasConceptScore W1967473008C204323151 @default.
• W1967473008 hasConceptScore W1967473008C30475298 @default.
• W1967473008 hasConceptScore W1967473008C33923547 @default.
• W1967473008 hasConceptScore W1967473008C4839761 @default.
• W1967473008 hasConceptScore W1967473008C62520636 @default.
• W1967473008 hasConceptScore W1967473008C86803240 @default.
• W1967473008 hasIssue "9" @default.
• W1967473008 hasLocation W19674730081 @default.
• W1967473008 hasOpenAccess W1967473008 @default.
• W1967473008 hasPrimaryLocation W19674730081 @default.

• next