FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967476444> ?p ?o ?g. }

• W1967476444 endingPage "727" @default.
• W1967476444 startingPage "719" @default.
• W1967476444 abstract "Background: The 3.0 Å crystal structure of the vitamin B12 RNA aptamer revealed an unusual tertiary structure that is rich in novel RNA structural motifs. Important details of the interactions that stabilize noncanonical base pairing and the role of solvent in the structure were not apparent owing to the limited resolution.Results: The structure of the vitamin B12 RNA aptamer in complex with its ligand has been determined at 2.3 Å resolution by X-ray crystallography. The crystallographic asymmetric unit contains five independent copies of the aptamer—vitamin B12 complex, making it possible to accurately define well-conserved features. The core of the aptamer contains an unusual water-filled channel that is buried between the three strands of an RNA triplex. Well-ordered water molecules positioned within this channel form bridging hydrogen bonds and stabilize planar base triples that otherwise lack significant direct base—base contacts. The water channel terminates at the interface between the RNA and the bound ligand, leaving a pair of water molecules appropriately positioned to hydrogen bond with the highly polarized cyanide nitrogen of vitamin B12. Analysis of the general solvation patterns for each nucleotide suggests that water molecules are not precisely positioned, as observed in previous RNA duplex structures, but instead might adjust in response to the varying local environment. Unusual intermolecular base pairing contributes to the formation of three different dimerization contacts that drive formation of the crystal lattice.Conclusions: The structure demonstrates the important role of water molecules and noncanonical base pairing in driving the formation of RNA tertiary structure and facilitating specific interactions of RNAs with other molecules." @default.
• W1967476444 created "2016-06-24" @default.
• W1967476444 creator A5025418128 @default.
• W1967476444 creator A5065718203 @default.
• W1967476444 date "2000-07-01" @default.
• W1967476444 modified "2023-09-23" @default.
• W1967476444 title "A water channel in the core of the vitamin B12 RNA aptamer" @default.
• W1967476444 cites W1906619597 @default.
• W1967476444 cites W1965252702 @default.
• W1967476444 cites W1971809659 @default.
• W1967476444 cites W1993226678 @default.
• W1967476444 cites W1995017064 @default.
• W1967476444 cites W2001641653 @default.
• W1967476444 cites W2007222863 @default.
• W1967476444 cites W2011722931 @default.
• W1967476444 cites W2019136531 @default.
• W1967476444 cites W2020909889 @default.
• W1967476444 cites W2022820623 @default.
• W1967476444 cites W2023668225 @default.
• W1967476444 cites W2026258231 @default.
• W1967476444 cites W2026817175 @default.
• W1967476444 cites W2029428843 @default.
• W1967476444 cites W2036088572 @default.
• W1967476444 cites W2036888427 @default.
• W1967476444 cites W2040882599 @default.
• W1967476444 cites W2041331047 @default.
• W1967476444 cites W2044247083 @default.
• W1967476444 cites W2047048575 @default.
• W1967476444 cites W2057465425 @default.
• W1967476444 cites W2072737163 @default.
• W1967476444 cites W2078248419 @default.
• W1967476444 cites W2081740530 @default.
• W1967476444 cites W2082040139 @default.
• W1967476444 cites W2083929510 @default.
• W1967476444 cites W2097335018 @default.
• W1967476444 cites W2128957368 @default.
• W1967476444 doi "https://doi.org/10.1016/s0969-2126(00)00159-3" @default.
• W1967476444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10903943" @default.
• W1967476444 hasPublicationYear "2000" @default.
• W1967476444 type Work @default.
• W1967476444 sameAs 1967476444 @default.
• W1967476444 citedByCount "21" @default.
• W1967476444 countsByYear W19674764442012 @default.
• W1967476444 countsByYear W19674764442013 @default.
• W1967476444 countsByYear W19674764442016 @default.
• W1967476444 countsByYear W19674764442018 @default.
• W1967476444 countsByYear W19674764442020 @default.
• W1967476444 countsByYear W19674764442022 @default.
• W1967476444 crossrefType "journal-article" @default.
• W1967476444 hasAuthorship W1967476444A5025418128 @default.
• W1967476444 hasAuthorship W1967476444A5065718203 @default.
• W1967476444 hasBestOaLocation W19674764441 @default.
• W1967476444 hasConcept C104317684 @default.
• W1967476444 hasConcept C10879258 @default.
• W1967476444 hasConcept C112887158 @default.
• W1967476444 hasConcept C115624301 @default.
• W1967476444 hasConcept C12554922 @default.
• W1967476444 hasConcept C126142528 @default.
• W1967476444 hasConcept C128972844 @default.
• W1967476444 hasConcept C148093993 @default.
• W1967476444 hasConcept C148625055 @default.
• W1967476444 hasConcept C178790620 @default.
• W1967476444 hasConcept C185581394 @default.
• W1967476444 hasConcept C185592680 @default.
• W1967476444 hasConcept C194993378 @default.
• W1967476444 hasConcept C32909587 @default.
• W1967476444 hasConcept C54355233 @default.
• W1967476444 hasConcept C552990157 @default.
• W1967476444 hasConcept C55493867 @default.
• W1967476444 hasConcept C67705224 @default.
• W1967476444 hasConcept C71240020 @default.
• W1967476444 hasConcept C8010536 @default.
• W1967476444 hasConcept C86803240 @default.
• W1967476444 hasConcept C99611785 @default.
• W1967476444 hasConceptScore W1967476444C104317684 @default.
• W1967476444 hasConceptScore W1967476444C10879258 @default.
• W1967476444 hasConceptScore W1967476444C112887158 @default.
• W1967476444 hasConceptScore W1967476444C115624301 @default.
• W1967476444 hasConceptScore W1967476444C12554922 @default.
• W1967476444 hasConceptScore W1967476444C126142528 @default.
• W1967476444 hasConceptScore W1967476444C128972844 @default.
• W1967476444 hasConceptScore W1967476444C148093993 @default.
• W1967476444 hasConceptScore W1967476444C148625055 @default.
• W1967476444 hasConceptScore W1967476444C178790620 @default.
• W1967476444 hasConceptScore W1967476444C185581394 @default.
• W1967476444 hasConceptScore W1967476444C185592680 @default.
• W1967476444 hasConceptScore W1967476444C194993378 @default.
• W1967476444 hasConceptScore W1967476444C32909587 @default.
• W1967476444 hasConceptScore W1967476444C54355233 @default.
• W1967476444 hasConceptScore W1967476444C552990157 @default.
• W1967476444 hasConceptScore W1967476444C55493867 @default.
• W1967476444 hasConceptScore W1967476444C67705224 @default.
• W1967476444 hasConceptScore W1967476444C71240020 @default.
• W1967476444 hasConceptScore W1967476444C8010536 @default.
• W1967476444 hasConceptScore W1967476444C86803240 @default.
• W1967476444 hasConceptScore W1967476444C99611785 @default.
• W1967476444 hasIssue "7" @default.
• W1967476444 hasLocation W19674764441 @default.

• next