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- W1967478077 abstract "Experiments from this and other laboratories have indicated that ethanol can both stimulate and depress cardiac function. Surmising that extracardiac stimuli, especially catecholamine release by alcohol, were obscuring its direct effect on the heart, studies were combined with autonomic blockade in anesthetized closed-chest dogs. Ethanol was infused at rates of 25 to 33 mg. per kilogram of body weight per minute; autonomic blockade was achieved with an initial dose of atropine 1.0 mg. per kilogram of body weight, and propranol 0.2 mg. per kilogram of body weight, and maintained by constant infusion. Cardiac performance was assessed from the Frank-Starling relation of ventricular filling pressure to cardiac work at control and at intervals after the start of infusions. Saline infusion with blockade caused no change in cardiac performance over 120 minutes. Ethanol with blockade caused progressive falls from 30 minutes on. Alcohol without blockade produced rises and falls in different animals in the first 30 minutes; thereafter, cardiac performance declined but at all intervals less than in dogs given alcohol with blockade. We concluded that alcohol uniformly depressed the heart after autonomic blockade, but without blockade this effect could be masked by extracardiac mechanisms mediated through the autonomic system. Assuming that catecholamine release was an important extracardiac mechanism, the conclusion was tested against conflicting reports in the literature and was found to be a useful hypothesis." @default.
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- W1967478077 date "1973-10-01" @default.
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- W1967478077 title "Depression of cardiac performance by ethanol unmasked during autonomic blockade" @default.
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- W1967478077 doi "https://doi.org/10.1016/0002-8703(73)90143-9" @default.
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