Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967492787> ?p ?o ?g. }
- W1967492787 endingPage "465" @default.
- W1967492787 startingPage "459" @default.
- W1967492787 abstract "The influence of cholesterol and the lovastatin (cholesterol-lowering drug) on secretion of α-secretase cleavage product of amyloid precursor protein (APP) and expression of nicotinic acetylcholine receptors (nAChRs) was investigated in human HTB-15 astrocytes. The results showed that exposure of cholesterol to astrocytes inhibited the secretion of α-form of secreted APP (αAPPs) and reduced cell viability, while lovastatin enhanced the α-secretase processing on astrocytes; cholesterol treatment decreased expression of α7 nAChR, whereas lovastatin induced an up-regulation of the receptor; the increase in αAPPs resulted from lovastatin was partially inhibited by the α7 nAChR antagonists, α-bungarotoxin or methyllycaconitine; cholesterol or lovastatin did not influence either whole APP level or expression of α4 nAChR. We suggest that high dose of cholesterol may inhibit both the activity of α-secretase in APP metabolic processing and the expression of α7 nAChR, while lovastatin may stimulate α-secretase cleavage processing that might be regulated by α7 nAChR." @default.
- W1967492787 created "2016-06-24" @default.
- W1967492787 creator A5001292166 @default.
- W1967492787 creator A5006616499 @default.
- W1967492787 creator A5052598913 @default.
- W1967492787 creator A5089411086 @default.
- W1967492787 date "2006-10-01" @default.
- W1967492787 modified "2023-10-02" @default.
- W1967492787 title "Influence of cholesterol and lovastatin on α-form of secreted amyloid precursor protein and expression of α7 nicotinic receptor on astrocytes" @default.
- W1967492787 cites W1500847299 @default.
- W1967492787 cites W1965050626 @default.
- W1967492787 cites W1968648927 @default.
- W1967492787 cites W1970602277 @default.
- W1967492787 cites W1974675375 @default.
- W1967492787 cites W1974715317 @default.
- W1967492787 cites W1975094715 @default.
- W1967492787 cites W1983417600 @default.
- W1967492787 cites W1984964878 @default.
- W1967492787 cites W1993943341 @default.
- W1967492787 cites W2009111659 @default.
- W1967492787 cites W2010476270 @default.
- W1967492787 cites W2021139758 @default.
- W1967492787 cites W2022127378 @default.
- W1967492787 cites W2029548011 @default.
- W1967492787 cites W2032551306 @default.
- W1967492787 cites W2035713503 @default.
- W1967492787 cites W2036839326 @default.
- W1967492787 cites W2041994355 @default.
- W1967492787 cites W2047613132 @default.
- W1967492787 cites W2063738580 @default.
- W1967492787 cites W2076215391 @default.
- W1967492787 cites W2080274663 @default.
- W1967492787 cites W2081586704 @default.
- W1967492787 cites W2090909076 @default.
- W1967492787 cites W2092060809 @default.
- W1967492787 cites W2094394444 @default.
- W1967492787 cites W2099556509 @default.
- W1967492787 cites W2108326377 @default.
- W1967492787 cites W2113934386 @default.
- W1967492787 cites W2150499586 @default.
- W1967492787 cites W2164956116 @default.
- W1967492787 cites W2168334242 @default.
- W1967492787 cites W2169152986 @default.
- W1967492787 cites W2301782268 @default.
- W1967492787 cites W4231255651 @default.
- W1967492787 cites W4252818752 @default.
- W1967492787 doi "https://doi.org/10.1016/j.neuint.2006.03.007" @default.
- W1967492787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16675062" @default.
- W1967492787 hasPublicationYear "2006" @default.
- W1967492787 type Work @default.
- W1967492787 sameAs 1967492787 @default.
- W1967492787 citedByCount "29" @default.
- W1967492787 countsByYear W19674927872012 @default.
- W1967492787 countsByYear W19674927872013 @default.
- W1967492787 countsByYear W19674927872014 @default.
- W1967492787 countsByYear W19674927872015 @default.
- W1967492787 countsByYear W19674927872017 @default.
- W1967492787 countsByYear W19674927872018 @default.
- W1967492787 countsByYear W19674927872021 @default.
- W1967492787 countsByYear W19674927872022 @default.
- W1967492787 crossrefType "journal-article" @default.
- W1967492787 hasAuthorship W1967492787A5001292166 @default.
- W1967492787 hasAuthorship W1967492787A5006616499 @default.
- W1967492787 hasAuthorship W1967492787A5052598913 @default.
- W1967492787 hasAuthorship W1967492787A5089411086 @default.
- W1967492787 hasConcept C104317684 @default.
- W1967492787 hasConcept C126322002 @default.
- W1967492787 hasConcept C134018914 @default.
- W1967492787 hasConcept C167400880 @default.
- W1967492787 hasConcept C170493617 @default.
- W1967492787 hasConcept C185592680 @default.
- W1967492787 hasConcept C188987157 @default.
- W1967492787 hasConcept C2777542381 @default.
- W1967492787 hasConcept C2778163477 @default.
- W1967492787 hasConcept C2779134260 @default.
- W1967492787 hasConcept C2779570518 @default.
- W1967492787 hasConcept C2780072125 @default.
- W1967492787 hasConcept C2780374058 @default.
- W1967492787 hasConcept C2780940807 @default.
- W1967492787 hasConcept C31705614 @default.
- W1967492787 hasConcept C36103677 @default.
- W1967492787 hasConcept C43554185 @default.
- W1967492787 hasConcept C49039625 @default.
- W1967492787 hasConcept C502032728 @default.
- W1967492787 hasConcept C529278444 @default.
- W1967492787 hasConcept C55493867 @default.
- W1967492787 hasConcept C63932345 @default.
- W1967492787 hasConcept C71924100 @default.
- W1967492787 hasConcept C86339819 @default.
- W1967492787 hasConcept C86803240 @default.
- W1967492787 hasConceptScore W1967492787C104317684 @default.
- W1967492787 hasConceptScore W1967492787C126322002 @default.
- W1967492787 hasConceptScore W1967492787C134018914 @default.
- W1967492787 hasConceptScore W1967492787C167400880 @default.
- W1967492787 hasConceptScore W1967492787C170493617 @default.
- W1967492787 hasConceptScore W1967492787C185592680 @default.
- W1967492787 hasConceptScore W1967492787C188987157 @default.
- W1967492787 hasConceptScore W1967492787C2777542381 @default.