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• W1967493670 abstract "Genomic signature maps of different cell types can aid in the interpretation of genomic data of specimens collected during disease states. We have defined “lineage-specific” genes, as well as “activation” genes, for cellular components of the skin: keratinocytes, fibroblasts, macrophages, monocytes, T cells, immature, and mature dendritic cells (DCs). Re-analysis of a previously published gene set of psoriasis then provided a model for assessing the usefulness of these maps. We were able to ascribe over 90% of these genes to specific cell types, and there was a surprisingly large contribution from DCs. This shows the utility of such cellular gene maps. Genomic signature maps of different cell types can aid in the interpretation of genomic data of specimens collected during disease states. We have defined “lineage-specific” genes, as well as “activation” genes, for cellular components of the skin: keratinocytes, fibroblasts, macrophages, monocytes, T cells, immature, and mature dendritic cells (DCs). Re-analysis of a previously published gene set of psoriasis then provided a model for assessing the usefulness of these maps. We were able to ascribe over 90% of these genes to specific cell types, and there was a surprisingly large contribution from DCs. This shows the utility of such cellular gene maps. dendritic cells lysosomal-associated membrane protein lymphotoxin beta peripheral blood mononuclear cells Rneasy lysis buffer tumor necrosis factor" @default.
• W1967493670 created "2016-06-24" @default.
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• W1967493670 date "2008-03-01" @default.
• W1967493670 modified "2023-09-27" @default.
• W1967493670 title "Cellular Genomic Maps Help Dissect Pathology in Human Skin Disease" @default.
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• W1967493670 doi "https://doi.org/10.1038/sj.jid.5701067" @default.
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