FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967514347> ?p ?o ?g. }

• W1967514347 endingPage "110" @default.
• W1967514347 startingPage "98" @default.
• W1967514347 abstract "The parkinsonian neurotoxin methylpyridinium (MPP(+)) mimics the neuropathology of Parkinson's disease (PD) and likely kills neurons by inhibiting complex I of the electron transport chain and increasing oxidative stress. We examined the time course of activation/inactivation of multiple pro- and anti-apoptotic signaling pathways in MPP(+)-induced apoptotic death of SH-SY5Y neuroblastoma cells. We found an early increase and later decrease of transcriptional activity of the generally anti-apoptotic nuclear factor kappa-beta (NF-kappa B) and early increases in activating phosphorylation of the anti-apoptotic upstream kinase protein kinase B (PKB, also known as AKT). Sequestration-inducing phosphorylation of pro-apoptotic BAD protein increased early then declined. A small biphasic increase in the generally pro-apoptotic p38 kinase activity paralleled the biphasic rise in NF-kappa B-mediated transcription. Inhibition of p38 kinase with 5 micro M SB203540, inhibition of MEK-ERK with 50 micro M U0126, or inhibition of phosphatidylinositol-3-kinase (PI3K) with 10 micro M LY294002 reduced cell viability by 4, 18 or 37%, respectively, after 24 h. All three kinase inhibitors increased cell death in response to 24 h of MPP(+), with the greatest effect shown by LY294002. Nerve growth factor (NGF) caused an early increase in activating phosphorylation of PKB/AKT and MEK-ERK and increased cell survival during MPP(+) exposure. We found that acute MPP(+) exposure activates multiple interacting death- and survival-promoting pathways. Survival-promoting MEK-ERK and PI3K pathways contribute to viability during MPP(+) exposure, both are activated by NGF, and loss of PI3K-mediated signaling and NF-kappa B-mediated transcription may commit cells irreversibly to apoptosis in this model. It remains unknown to what extent these signaling pathways modulate dopamine neuronal death in PD." @default.
• W1967514347 created "2016-06-24" @default.
• W1967514347 creator A5037738083 @default.
• W1967514347 creator A5052947692 @default.
• W1967514347 creator A5059595648 @default.
• W1967514347 creator A5062220925 @default.
• W1967514347 creator A5063292982 @default.
• W1967514347 creator A5083542020 @default.
• W1967514347 date "2002-10-01" @default.
• W1967514347 modified "2023-10-16" @default.
• W1967514347 title "Methylpyridinium (MPP+)- and nerve growth factor-induced changes in pro- and anti-apoptotic signaling pathways in SH-SY5Y neuroblastoma cells" @default.
• W1967514347 cites W12631990 @default.
• W1967514347 cites W1480466711 @default.
• W1967514347 cites W1515578871 @default.
• W1967514347 cites W1522510037 @default.
• W1967514347 cites W1545645579 @default.
• W1967514347 cites W1558654722 @default.
• W1967514347 cites W1562884473 @default.
• W1967514347 cites W1606738305 @default.
• W1967514347 cites W1617532721 @default.
• W1967514347 cites W1914067219 @default.
• W1967514347 cites W1965575645 @default.
• W1967514347 cites W1967861082 @default.
• W1967514347 cites W1975823509 @default.
• W1967514347 cites W1976441097 @default.
• W1967514347 cites W1980935526 @default.
• W1967514347 cites W1983347726 @default.
• W1967514347 cites W1983398917 @default.
• W1967514347 cites W1987035130 @default.
• W1967514347 cites W1989405078 @default.
• W1967514347 cites W1991804565 @default.
• W1967514347 cites W1993216157 @default.
• W1967514347 cites W1996405087 @default.
• W1967514347 cites W2005853389 @default.
• W1967514347 cites W2007822968 @default.
• W1967514347 cites W2017857028 @default.
• W1967514347 cites W2020184457 @default.
• W1967514347 cites W2024880806 @default.
• W1967514347 cites W2024917983 @default.
• W1967514347 cites W2028151158 @default.
• W1967514347 cites W2030453966 @default.
• W1967514347 cites W2030573603 @default.
• W1967514347 cites W2040558323 @default.
• W1967514347 cites W2042196731 @default.
• W1967514347 cites W2044868069 @default.
• W1967514347 cites W2047826668 @default.
• W1967514347 cites W2048012950 @default.
• W1967514347 cites W2053185662 @default.
• W1967514347 cites W2053252892 @default.
• W1967514347 cites W2066671615 @default.
• W1967514347 cites W2069104210 @default.
• W1967514347 cites W2074783627 @default.
• W1967514347 cites W2077321849 @default.
• W1967514347 cites W2077342956 @default.
• W1967514347 cites W2079231229 @default.
• W1967514347 cites W2088472722 @default.
• W1967514347 cites W2091720251 @default.
• W1967514347 cites W2092066822 @default.
• W1967514347 cites W2093190673 @default.
• W1967514347 cites W2094155854 @default.
• W1967514347 cites W2096298540 @default.
• W1967514347 cites W2097767970 @default.
• W1967514347 cites W2102410706 @default.
• W1967514347 cites W2104409043 @default.
• W1967514347 cites W2112620000 @default.
• W1967514347 cites W2112933076 @default.
• W1967514347 cites W2128960139 @default.
• W1967514347 cites W2138892400 @default.
• W1967514347 cites W2143944971 @default.
• W1967514347 cites W2144011146 @default.
• W1967514347 cites W2147114673 @default.
• W1967514347 cites W2155395884 @default.
• W1967514347 cites W2158730778 @default.
• W1967514347 cites W2164314374 @default.
• W1967514347 cites W2166655452 @default.
• W1967514347 cites W2169724245 @default.
• W1967514347 cites W2172170767 @default.
• W1967514347 cites W2329681473 @default.
• W1967514347 doi "https://doi.org/10.1016/s0006-8993(02)03216-x" @default.
• W1967514347 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12363409" @default.
• W1967514347 hasPublicationYear "2002" @default.
• W1967514347 type Work @default.
• W1967514347 sameAs 1967514347 @default.
• W1967514347 citedByCount "56" @default.
• W1967514347 countsByYear W19675143472012 @default.
• W1967514347 countsByYear W19675143472013 @default.
• W1967514347 countsByYear W19675143472014 @default.
• W1967514347 countsByYear W19675143472015 @default.
• W1967514347 countsByYear W19675143472016 @default.
• W1967514347 countsByYear W19675143472017 @default.
• W1967514347 countsByYear W19675143472018 @default.
• W1967514347 countsByYear W19675143472019 @default.
• W1967514347 crossrefType "journal-article" @default.
• W1967514347 hasAuthorship W1967514347A5037738083 @default.
• W1967514347 hasAuthorship W1967514347A5052947692 @default.
• W1967514347 hasAuthorship W1967514347A5059595648 @default.
• W1967514347 hasAuthorship W1967514347A5062220925 @default.
• W1967514347 hasAuthorship W1967514347A5063292982 @default.

• next