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- W1967517308 abstract "Male rats, 90–100 days old, with frontal cortex lesions were given either subcutaneous sterile water (SW) as a vehicle control or 1, 10, or 100 μg of BIM-22015 every other day for 20 days. Brain-injured subjects tested in the Morris water maze with either 10 μg BIM-22015 or SW took significantly more trials than sham-operated rats to locate a submerged platform eight consecutive times within 60 s. The animals given 1 or 100 μg BIM-22015 took significantly fewer trials to reach criterion than brain-injured animals in the other drug treatment groups. On a percentage of savings, measured 8 days after reaching criterion, the brain-injured subjects given 1, 10, or 100 μg BIM-22015 did not differ from sham-operated rats. In contrast, the brain-injured animals given SW took longer to find the submerged platform than they did during the initial training. To assess long-term effects of the ACTH analog treatment, rats were trained on a delayed spatial alternation task 30 days after receiving the last injection. On this task, brain-injured rats treated with the 10-μg dose performed significantly better than those given sterile water. Acetylcholinesterase (AChE)-labeled neurons counted in the nucleus basalis magnocellularis indicated that rats with frontal cortex damage given the 10-μg treatment did not differ from the sham controls and had significantly more AChE-positive neurons than injured counterparts treated with SW or 100 μg." @default.
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- W1967517308 date "1992-03-01" @default.
- W1967517308 modified "2023-10-17" @default.
- W1967517308 title "Effects of BIM-22015, an analog of ACTH4–10, on functional recovery after frontal cortex injury" @default.
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- W1967517308 doi "https://doi.org/10.1016/0163-1047(92)90665-q" @default.
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