Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967521605> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1967521605 endingPage "1222" @default.
- W1967521605 startingPage "1211" @default.
- W1967521605 abstract "Rats, injected with small doses of amphetamine (0.03-0.1 mg/kg, i.p.), showed an increase in the soluble and a decrease in the activity of the particulate protein kinase C (PKC) in the striatum, while large doses of amphetamine (0.3-1.0 mg/kg) had the opposite effect of decreasing the soluble and increasing the particulate activity of PKC. These effects were manifested as a change in the Km for calcium, without an alteration in the Vmax. They were attenuated by pretreatment with benztropine, a dopamine (DA) uptake blocker and by alpha-methyl-p-tyrosine (alpha-MT), a DA synthesis inhibitor. The effects of 0.1 mg/kg amphetamine were insensitive to pretreatment with reserpine but were attenuated by the DA antagonists, SCH 23390 or sulpiride. These results suggest that the changes in activity of PKC induced by a small dose of amphetamine were mediated by an activation of DA autoreceptors, through an increase in the biophase concentration of DA at the synapse. In contrast, the effects of 1.0 mg/kg amphetamine on activity of PKC were attenuated by reserpine and by the DA agonists, LY 171555 or SKF 38393. They were, furthermore, potentiated by simultaneous treatment with sulpiride, which indicates that the two drugs act by different mechanisms. These results suggest that larger doses of amphetamine altered the activity of PKC at the DA transport site." @default.
- W1967521605 created "2016-06-24" @default.
- W1967521605 creator A5079322359 @default.
- W1967521605 date "1992-12-01" @default.
- W1967521605 modified "2023-09-23" @default.
- W1967521605 title "Protein kinase C and dopamine transport—2. Effects of amphetamine in vitro" @default.
- W1967521605 cites W1590165734 @default.
- W1967521605 cites W1751807524 @default.
- W1967521605 cites W1994429247 @default.
- W1967521605 cites W1998293863 @default.
- W1967521605 cites W2007453287 @default.
- W1967521605 cites W2030854164 @default.
- W1967521605 cites W2065063347 @default.
- W1967521605 cites W2071907851 @default.
- W1967521605 cites W2365555452 @default.
- W1967521605 cites W4234186473 @default.
- W1967521605 doi "https://doi.org/10.1016/0028-3908(92)90049-u" @default.
- W1967521605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1361666" @default.
- W1967521605 hasPublicationYear "1992" @default.
- W1967521605 type Work @default.
- W1967521605 sameAs 1967521605 @default.
- W1967521605 citedByCount "87" @default.
- W1967521605 countsByYear W19675216052012 @default.
- W1967521605 countsByYear W19675216052014 @default.
- W1967521605 countsByYear W19675216052015 @default.
- W1967521605 countsByYear W19675216052016 @default.
- W1967521605 countsByYear W19675216052017 @default.
- W1967521605 countsByYear W19675216052018 @default.
- W1967521605 countsByYear W19675216052019 @default.
- W1967521605 countsByYear W19675216052021 @default.
- W1967521605 countsByYear W19675216052022 @default.
- W1967521605 countsByYear W19675216052023 @default.
- W1967521605 crossrefType "journal-article" @default.
- W1967521605 hasAuthorship W1967521605A5079322359 @default.
- W1967521605 hasConcept C126322002 @default.
- W1967521605 hasConcept C134018914 @default.
- W1967521605 hasConcept C137183658 @default.
- W1967521605 hasConcept C170493617 @default.
- W1967521605 hasConcept C184235292 @default.
- W1967521605 hasConcept C185592680 @default.
- W1967521605 hasConcept C195794163 @default.
- W1967521605 hasConcept C2775864247 @default.
- W1967521605 hasConcept C2776885963 @default.
- W1967521605 hasConcept C2777078754 @default.
- W1967521605 hasConcept C2777193897 @default.
- W1967521605 hasConcept C2777842393 @default.
- W1967521605 hasConcept C2780806966 @default.
- W1967521605 hasConcept C513476851 @default.
- W1967521605 hasConcept C55493867 @default.
- W1967521605 hasConcept C71924100 @default.
- W1967521605 hasConcept C8439214 @default.
- W1967521605 hasConcept C86803240 @default.
- W1967521605 hasConcept C98274493 @default.
- W1967521605 hasConceptScore W1967521605C126322002 @default.
- W1967521605 hasConceptScore W1967521605C134018914 @default.
- W1967521605 hasConceptScore W1967521605C137183658 @default.
- W1967521605 hasConceptScore W1967521605C170493617 @default.
- W1967521605 hasConceptScore W1967521605C184235292 @default.
- W1967521605 hasConceptScore W1967521605C185592680 @default.
- W1967521605 hasConceptScore W1967521605C195794163 @default.
- W1967521605 hasConceptScore W1967521605C2775864247 @default.
- W1967521605 hasConceptScore W1967521605C2776885963 @default.
- W1967521605 hasConceptScore W1967521605C2777078754 @default.
- W1967521605 hasConceptScore W1967521605C2777193897 @default.
- W1967521605 hasConceptScore W1967521605C2777842393 @default.
- W1967521605 hasConceptScore W1967521605C2780806966 @default.
- W1967521605 hasConceptScore W1967521605C513476851 @default.
- W1967521605 hasConceptScore W1967521605C55493867 @default.
- W1967521605 hasConceptScore W1967521605C71924100 @default.
- W1967521605 hasConceptScore W1967521605C8439214 @default.
- W1967521605 hasConceptScore W1967521605C86803240 @default.
- W1967521605 hasConceptScore W1967521605C98274493 @default.
- W1967521605 hasIssue "12" @default.
- W1967521605 hasLocation W19675216051 @default.
- W1967521605 hasLocation W19675216052 @default.
- W1967521605 hasOpenAccess W1967521605 @default.
- W1967521605 hasPrimaryLocation W19675216051 @default.
- W1967521605 hasRelatedWork W1925373942 @default.
- W1967521605 hasRelatedWork W1966875503 @default.
- W1967521605 hasRelatedWork W1983992005 @default.
- W1967521605 hasRelatedWork W1989459745 @default.
- W1967521605 hasRelatedWork W2027942102 @default.
- W1967521605 hasRelatedWork W2042152132 @default.
- W1967521605 hasRelatedWork W2059223423 @default.
- W1967521605 hasRelatedWork W2078363292 @default.
- W1967521605 hasRelatedWork W2260961203 @default.
- W1967521605 hasRelatedWork W55439675 @default.
- W1967521605 hasVolume "31" @default.
- W1967521605 isParatext "false" @default.
- W1967521605 isRetracted "false" @default.
- W1967521605 magId "1967521605" @default.
- W1967521605 workType "article" @default.