FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967530175> ?p ?o ?g. }

• W1967530175 endingPage "e12519" @default.
• W1967530175 startingPage "e12519" @default.
• W1967530175 abstract "Senescence is a highly regulated process that limits cellular replication by enforcing a G1 arrest in response to various stimuli. Replicative senescence occurs in response to telomeric DNA erosion, and telomerase expression can offset replicative senescence leading to immortalization of many human cells. Limited data exists regarding changes of microRNA (miRNA) expression during senescence in human cells and no reports correlate telomerase expression with regulation of senescence-related miRNAs. We used miRNA microarrays to provide a detailed account of miRNA profiles for early passage and senescent human foreskin (BJ) fibroblasts as well as early and late passage immortalized fibroblasts (BJ-hTERT) that stably express the human telomerase reverse transcriptase subunit hTERT. Selected miRNAs that were differentially expressed in senescence were assayed for expression in quiescent cells to identify miRNAs that are specifically associated with senescence-associated growth arrest. From this group of senescence-associated miRNAs, we confirmed the ability of miR-143 to induce growth arrest after ectopic expression in young fibroblasts. Remarkably, miR-143 failed to induce growth arrest in BJ-hTERT cells. Importantly, the comparison of late passage immortalized fibroblasts to senescent wild type fibroblasts reveals that miR-146a, a miRNA with a validated role in regulating the senescence associated secretory pathway, is also regulated during extended cell culture independently of senescence. The discovery that miRNA expression is impacted by expression of ectopic hTERT as well as extended passaging in immortalized fibroblasts contributes to a comprehensive understanding of the connections between telomerase expression, senescence and processes of cellular aging." @default.
• W1967530175 created "2016-06-24" @default.
• W1967530175 creator A5041868084 @default.
• W1967530175 creator A5084674677 @default.
• W1967530175 date "2010-09-01" @default.
• W1967530175 modified "2023-09-23" @default.
• W1967530175 title "MiRNA Profile Associated with Replicative Senescence, Extended Cell Culture, and Ectopic Telomerase Expression in Human Foreskin Fibroblasts" @default.
• W1967530175 cites W1524571013 @default.
• W1967530175 cites W1536144403 @default.
• W1967530175 cites W1984936995 @default.
• W1967530175 cites W1992363536 @default.
• W1967530175 cites W2004273407 @default.
• W1967530175 cites W2027542963 @default.
• W1967530175 cites W2036923470 @default.
• W1967530175 cites W2039669402 @default.
• W1967530175 cites W2047262284 @default.
• W1967530175 cites W2047438086 @default.
• W1967530175 cites W2047833751 @default.
• W1967530175 cites W2049660571 @default.
• W1967530175 cites W2053863057 @default.
• W1967530175 cites W2061452886 @default.
• W1967530175 cites W2061619522 @default.
• W1967530175 cites W2063864717 @default.
• W1967530175 cites W2074210527 @default.
• W1967530175 cites W2075808770 @default.
• W1967530175 cites W2080084006 @default.
• W1967530175 cites W2086316954 @default.
• W1967530175 cites W2089970049 @default.
• W1967530175 cites W2111065446 @default.
• W1967530175 cites W2112758818 @default.
• W1967530175 cites W2114840351 @default.
• W1967530175 cites W2120126501 @default.
• W1967530175 cites W2137881107 @default.
• W1967530175 cites W2144154026 @default.
• W1967530175 cites W2150932906 @default.
• W1967530175 cites W2157456513 @default.
• W1967530175 cites W2161224111 @default.
• W1967530175 cites W2167021978 @default.
• W1967530175 cites W4238545515 @default.
• W1967530175 doi "https://doi.org/10.1371/journal.pone.0012519" @default.
• W1967530175 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2931704" @default.
• W1967530175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20824140" @default.
• W1967530175 hasPublicationYear "2010" @default.
• W1967530175 type Work @default.
• W1967530175 sameAs 1967530175 @default.
• W1967530175 citedByCount "68" @default.
• W1967530175 countsByYear W19675301752012 @default.
• W1967530175 countsByYear W19675301752013 @default.
• W1967530175 countsByYear W19675301752014 @default.
• W1967530175 countsByYear W19675301752015 @default.
• W1967530175 countsByYear W19675301752016 @default.
• W1967530175 countsByYear W19675301752017 @default.
• W1967530175 countsByYear W19675301752018 @default.
• W1967530175 countsByYear W19675301752020 @default.
• W1967530175 countsByYear W19675301752021 @default.
• W1967530175 countsByYear W19675301752022 @default.
• W1967530175 countsByYear W19675301752023 @default.
• W1967530175 crossrefType "journal-article" @default.
• W1967530175 hasAuthorship W1967530175A5041868084 @default.
• W1967530175 hasAuthorship W1967530175A5084674677 @default.
• W1967530175 hasBestOaLocation W19675301751 @default.
• W1967530175 hasConcept C104317684 @default.
• W1967530175 hasConcept C125593758 @default.
• W1967530175 hasConcept C145059251 @default.
• W1967530175 hasConcept C153911025 @default.
• W1967530175 hasConcept C177336024 @default.
• W1967530175 hasConcept C522857546 @default.
• W1967530175 hasConcept C54355233 @default.
• W1967530175 hasConcept C6045943 @default.
• W1967530175 hasConcept C81885089 @default.
• W1967530175 hasConcept C86803240 @default.
• W1967530175 hasConcept C94581717 @default.
• W1967530175 hasConcept C95444343 @default.
• W1967530175 hasConcept C97037327 @default.
• W1967530175 hasConceptScore W1967530175C104317684 @default.
• W1967530175 hasConceptScore W1967530175C125593758 @default.
• W1967530175 hasConceptScore W1967530175C145059251 @default.
• W1967530175 hasConceptScore W1967530175C153911025 @default.
• W1967530175 hasConceptScore W1967530175C177336024 @default.
• W1967530175 hasConceptScore W1967530175C522857546 @default.
• W1967530175 hasConceptScore W1967530175C54355233 @default.
• W1967530175 hasConceptScore W1967530175C6045943 @default.
• W1967530175 hasConceptScore W1967530175C81885089 @default.
• W1967530175 hasConceptScore W1967530175C86803240 @default.
• W1967530175 hasConceptScore W1967530175C94581717 @default.
• W1967530175 hasConceptScore W1967530175C95444343 @default.
• W1967530175 hasConceptScore W1967530175C97037327 @default.
• W1967530175 hasIssue "9" @default.
• W1967530175 hasLocation W19675301751 @default.
• W1967530175 hasLocation W19675301752 @default.
• W1967530175 hasLocation W19675301753 @default.
• W1967530175 hasLocation W19675301754 @default.
• W1967530175 hasLocation W19675301755 @default.
• W1967530175 hasOpenAccess W1967530175 @default.
• W1967530175 hasPrimaryLocation W19675301751 @default.
• W1967530175 hasRelatedWork W1967530175 @default.
• W1967530175 hasRelatedWork W1967762572 @default.
• W1967530175 hasRelatedWork W1977279007 @default.

• next