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- W1967534757 abstract "The polypeptides bradykinin, kallidin and eledoisin were more potent vasoconstrictors in an isolated blood-perfused rabbit lung preparation than were noradrenaline, 5-hydroxytryptamine and histamine. Acetylcholine was, however, even more potent as a vasoconstrictor in the preparation than were the three polypeptides. The polypeptides were apparently not acting via a liberation into the perfusate of circulating noradrenaline, 5-hydroxytryptamine or histamine. Bradykinin and kallidin both showed some tachyphylaxis, and also cross-tachyphylaxis, indicating a common site of action. Eledoisin showed a very marked tachy-phylaxis, but no cross-tachyphylaxis towards the two other peptides, indicating a different site of action from that of bradykinin and kallidin. Phenylbutazone and sodium salicylate reduced the responses to plasma kinin injections by some 30–60 per cent, but nonspecifically, as e.g. 5-hydroxytryptamine responses were reduced to the same extent." @default.
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- W1967534757 date "1966-03-01" @default.
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- W1967534757 title "The Effect of Bradykinin, Kallidin and Eledoisin upon the Pulmonary Vascular Bed of an Isolated Blood-Perfused Rabbit Lung Preparation" @default.
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- W1967534757 doi "https://doi.org/10.1111/j.1748-1716.1966.tb03199.x" @default.
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