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• W1967546222 startingPage "109" @default.
• W1967546222 abstract "Endometrial fibroblasts derived from uterine endometrium as controls and endometrial cancer cell lines (Ishikawa and HHUA cells) were analyzed for the induction manner of c-fos and c-jun transcripts in endometrial cancers, some of which are estrogen-dependent in growth. Estrogen increased c-fos expression and protein kinase C (PKC) activity in fibroblasts and Ishikawa cells, but not in HHUA cells. Progesterone diminished c-fos and c-jun expression and PKC activity induced by estradiol in the fibroblasts, but not in Ishikawa cells, which persistently overexpressed c-fos and c-jun. In these cells, 12-0-tetra-decanoylphorbol-13-acetate (TPA) increased c-fos and c-jun expression as did estradiol. Pretreatment with 1-(5-isoqrrinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) abolished estrogen-inducible over-expression of c-fos arid c-jun. The combination of both estradiol and TPA at maximum effective concentration exerted no additive and syneugistic effect on induction of c-fos and c-jun expression.In conclusion, persistent activation of PKC might lead to overexpression of c-fos and c-jun in some endometrial cancers with an estrogen predominant milieu, which might be, at least in part, associated with the transformation or growth potential." @default.
• W1967546222 created "2016-06-24" @default.
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• W1967546222 date "1996-01-01" @default.
• W1967546222 modified "2023-09-24" @default.
• W1967546222 title "Estrogen induces expression of<i>c-fos</i>and<i>c-jun</i>via activation of protein kinase C in an endometrial cancer cell line and fibroblasts derived from human uterine endometrium" @default.
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• W1967546222 doi "https://doi.org/10.3109/09513599609097900" @default.
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