Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967555854> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1967555854 endingPage "S8" @default.
- W1967555854 startingPage "S3" @default.
- W1967555854 abstract "Bronchial biopsy provides valuable information about the inflammatory processes in lung tissue, but optimal results are only achieved if the design of intervention studies is sufficiently rigorous. The parallel-group design has merit, but the cross-over design is statistically superior, providing the wash-out period is effective. Heterogeneity of contributing pathologies in asthma patients results in large inter-patient variability which must be controlled for, for example by using strict inclusion criteria, which should ideally relate to the specific inflammatory marker being studied. The inclusion of a placebo group helps to quantify sample variability. The study must have sufficient statistical power to detect inter-group differences for each variable; appropriate adjustments should be made when multiple tests are used. Studies with larger patient numbers are best performed using a multi-centre design, with one centre analysing all tissue samples to reduce variability. Study duration depends on the type of investigation, but should ideally be short. Longer studies are necessary to evaluate chronic changes such as tissue remodelling. Changes in clinical status and cellular events may follow different time courses after intervention. Biopsy measurements are less reproducible than physiological tests, and diurnal variation in the number and function of inflammatory cells can further complicate measurement. The timing of clinical trial assessments needs to allow for these idiosyncrasies. Finally, a balance must be maintained between the risk, albeit small, and the benefit of performing bronchial biopsies." @default.
- W1967555854 created "2016-06-24" @default.
- W1967555854 creator A5013095319 @default.
- W1967555854 creator A5029053668 @default.
- W1967555854 creator A5061402126 @default.
- W1967555854 creator A5066207809 @default.
- W1967555854 date "2000-10-01" @default.
- W1967555854 modified "2023-09-30" @default.
- W1967555854 title "Designing bronchial biopsy studies" @default.
- W1967555854 cites W1869362176 @default.
- W1967555854 cites W1951453186 @default.
- W1967555854 cites W1968893425 @default.
- W1967555854 cites W1977093939 @default.
- W1967555854 cites W1977474311 @default.
- W1967555854 cites W1993139879 @default.
- W1967555854 cites W1993997407 @default.
- W1967555854 cites W1996696073 @default.
- W1967555854 cites W2009564102 @default.
- W1967555854 cites W2013557181 @default.
- W1967555854 cites W2016835468 @default.
- W1967555854 cites W2063118615 @default.
- W1967555854 cites W2072413258 @default.
- W1967555854 cites W2090359531 @default.
- W1967555854 cites W2121474582 @default.
- W1967555854 cites W2122486304 @default.
- W1967555854 cites W2152051888 @default.
- W1967555854 cites W2337807480 @default.
- W1967555854 doi "https://doi.org/10.1016/s0954-6111(00)90126-4" @default.
- W1967555854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11059961" @default.
- W1967555854 hasPublicationYear "2000" @default.
- W1967555854 type Work @default.
- W1967555854 sameAs 1967555854 @default.
- W1967555854 citedByCount "1" @default.
- W1967555854 countsByYear W19675558542014 @default.
- W1967555854 crossrefType "journal-article" @default.
- W1967555854 hasAuthorship W1967555854A5013095319 @default.
- W1967555854 hasAuthorship W1967555854A5029053668 @default.
- W1967555854 hasAuthorship W1967555854A5061402126 @default.
- W1967555854 hasAuthorship W1967555854A5066207809 @default.
- W1967555854 hasBestOaLocation W19675558541 @default.
- W1967555854 hasConcept C105795698 @default.
- W1967555854 hasConcept C126322002 @default.
- W1967555854 hasConcept C129848803 @default.
- W1967555854 hasConcept C142724271 @default.
- W1967555854 hasConcept C148482608 @default.
- W1967555854 hasConcept C204787440 @default.
- W1967555854 hasConcept C27081682 @default.
- W1967555854 hasConcept C2775934546 @default.
- W1967555854 hasConcept C2776042228 @default.
- W1967555854 hasConcept C33923547 @default.
- W1967555854 hasConcept C535046627 @default.
- W1967555854 hasConcept C71924100 @default.
- W1967555854 hasConcept C96608239 @default.
- W1967555854 hasConceptScore W1967555854C105795698 @default.
- W1967555854 hasConceptScore W1967555854C126322002 @default.
- W1967555854 hasConceptScore W1967555854C129848803 @default.
- W1967555854 hasConceptScore W1967555854C142724271 @default.
- W1967555854 hasConceptScore W1967555854C148482608 @default.
- W1967555854 hasConceptScore W1967555854C204787440 @default.
- W1967555854 hasConceptScore W1967555854C27081682 @default.
- W1967555854 hasConceptScore W1967555854C2775934546 @default.
- W1967555854 hasConceptScore W1967555854C2776042228 @default.
- W1967555854 hasConceptScore W1967555854C33923547 @default.
- W1967555854 hasConceptScore W1967555854C535046627 @default.
- W1967555854 hasConceptScore W1967555854C71924100 @default.
- W1967555854 hasConceptScore W1967555854C96608239 @default.
- W1967555854 hasLocation W19675558541 @default.
- W1967555854 hasLocation W19675558542 @default.
- W1967555854 hasOpenAccess W1967555854 @default.
- W1967555854 hasPrimaryLocation W19675558541 @default.
- W1967555854 hasRelatedWork W1986222379 @default.
- W1967555854 hasRelatedWork W2028545055 @default.
- W1967555854 hasRelatedWork W2082770695 @default.
- W1967555854 hasRelatedWork W2327291419 @default.
- W1967555854 hasRelatedWork W2407635962 @default.
- W1967555854 hasRelatedWork W2434403408 @default.
- W1967555854 hasRelatedWork W2773514871 @default.
- W1967555854 hasRelatedWork W2888888819 @default.
- W1967555854 hasRelatedWork W3208091253 @default.
- W1967555854 hasRelatedWork W4313332390 @default.
- W1967555854 hasVolume "94" @default.
- W1967555854 isParatext "false" @default.
- W1967555854 isRetracted "false" @default.
- W1967555854 magId "1967555854" @default.
- W1967555854 workType "article" @default.