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- W1967563231 abstract "Local injection of a potent poison—Clostridium botulinumtoxin—may bring relief to sufferers of benign essential blepharospasm (Arch Ophthal1985;103:347-350). This disorder, which tends to afflict persons of middle years and beyond, is characterized by an involuntary spasm of (usually) both obicularis oculi muscles, resulting in uncontrollable eyelid closure and functional blindness. Botulinum toxin, which acts by blocking the release of acetylcholine from the presynaptic nerve terminal, causes paralysis of the overactive facial muscles, allowing the eyes to remain open. Alan B. Scott, MD, associate director, Smith-Kettlewell Institute of Visual Sciences, Medical Research Institute of San Francisco, told the Research to Prevent Blindness seminar of results of a collaborative study, supported in part by the National Eye Institute, of 442 patients afflicted with this disorder. Beneficial effect of the botulinum toxin therapy has been reported in over 90% of the patients. A preparation of the toxin (.001μg/mL) is injected at" @default.
- W1967563231 created "2016-06-24" @default.
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- W1967563231 date "1985-10-04" @default.
- W1967563231 modified "2023-09-27" @default.
- W1967563231 title "Botulinum toxin may help blepharospasm sufferers" @default.
- W1967563231 doi "https://doi.org/10.1001/jama.1985.03360130018004" @default.
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