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- W1967564440 abstract "1. The recruiting response has been studied in the rat with special reference to the effects of thyroidectomy and subsequent replacement therapy. 2. Neonatal thyroidectomy is associated in later life with an increase in the latency and duration of the surface-negative component of the response and a reduction in its amplitude. 3. Medication with 1-triiodothyronine for 2 days prior to recording restores latency and duration to within normal range but is without effect on the amplitude of the response. Acute administration of this hormone during the process of recording is without significant effect on any parameter. 4. Thyroidectomy during adult life results in an increase in both the latency and duration of the negative wave, but does not alter the amplitude of the response. 5. These findings are discussed in the light of structural and metabolic differences between the brains of rats made hypothyroid during the course of cerebral development and after such development is complete. It is thought that they conform well with the view that the amplitude of the recruiting response may reflect the envelope of post-synaptic dendritic potentials whose number is significantly reduced in the neo-natally thyroidectomised individual whereas its latency and duration, while not necessarily independent of structure, are more readily regulated by metabolic factors." @default.
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- W1967564440 date "1961-08-01" @default.
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- W1967564440 title "The maturational and metabolic consequences of neonatal thyroidectomy upon the recruiting response in the rat" @default.
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- W1967564440 doi "https://doi.org/10.1016/0013-4694(61)90171-7" @default.
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