FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967579647> ?p ?o ?g. }

• W1967579647 endingPage "297" @default.
• W1967579647 startingPage "289" @default.
• W1967579647 abstract "Background: Distribution of HIV-1 subtypes, transmitted drug resistance (TDR)/drug resistance mutation (DRM), and their impact on response to combination antiretroviral therapy remain poorly understood in China. Methods: We analyzed data from our multicenter cohort study with 444 antiretroviral-naive participants recruited between 2008 and 2010. HIV-1 subtype and tropism were determined by V3 sequencing, and TDR/DRM was determined by Pol sequencing. Virologic and immunologic responses were monitored over 96 weeks of follow-up. The initial combination antiretroviral therapy regimen for all patients was nevirapine + lamivudine + zidovudine or stavudine. Analysis 1 included patients who finished 96 weeks of follow-up (n = 379), and analysis 2 included all 444 patients. Results: Subtype B/B′ was associated with higher prevalence of TDR/DRM to nucleoside reverse transcriptase inhibitors and nonnucleoside reverse transcriptase inhibitors. Median time to HIV-1 suppression was 18 weeks in all 3 subtype groups. In Cox proportional models for viral suppression, neither viral tropism nor HIV-1 subtypes had any impact on viral suppression; however, subtypes CRF01_AE and C/CRF07_BC/CRF08_BC were associated with lower risk of virologic failure compared with subtype B/B′, with adjusted hazard ratio of 0.11 (P = 0.032) and 0.06 (P = 0.036), respectively in analysis 1, 0.42 (P = 0.047) and 0.22 (P = 0.008), respectively in analysis 2. This association was attenuated by adding DRM profiles to multivariate regression models. Neither subtype nor HIV-1 tropism affected immunologic response. Conclusions: HIV-1 subtype tended to be associated with virologic but not immunologic response; this effect could be ascribed to baseline DRM." @default.
• W1967579647 created "2016-06-24" @default.
• W1967579647 creator A5028609590 @default.
• W1967579647 creator A5031880803 @default.
• W1967579647 creator A5031998757 @default.
• W1967579647 creator A5033709878 @default.
• W1967579647 creator A5044293886 @default.
• W1967579647 creator A5044459845 @default.
• W1967579647 creator A5051817115 @default.
• W1967579647 creator A5055819465 @default.
• W1967579647 creator A5067750617 @default.
• W1967579647 creator A5075051424 @default.
• W1967579647 creator A5084027922 @default.
• W1967579647 date "2015-03-01" @default.
• W1967579647 modified "2023-10-18" @default.
• W1967579647 title "HIV-1 Subtype B/B′ and Baseline Drug Resistance Mutation Are Associated With Virologic Failure" @default.
• W1967579647 cites W143018193 @default.
• W1967579647 cites W1923976651 @default.
• W1967579647 cites W1951605797 @default.
• W1967579647 cites W1981050735 @default.
• W1967579647 cites W1993942319 @default.
• W1967579647 cites W1995973760 @default.
• W1967579647 cites W2001728079 @default.
• W1967579647 cites W2008706768 @default.
• W1967579647 cites W2016258101 @default.
• W1967579647 cites W2018761667 @default.
• W1967579647 cites W2020461877 @default.
• W1967579647 cites W2028115726 @default.
• W1967579647 cites W2044994287 @default.
• W1967579647 cites W2051499965 @default.
• W1967579647 cites W2053469170 @default.
• W1967579647 cites W2059054362 @default.
• W1967579647 cites W2067729283 @default.
• W1967579647 cites W2084881977 @default.
• W1967579647 cites W2085614502 @default.
• W1967579647 cites W2085688632 @default.
• W1967579647 cites W2086143491 @default.
• W1967579647 cites W2095675185 @default.
• W1967579647 cites W2100163253 @default.
• W1967579647 cites W2105013761 @default.
• W1967579647 cites W2109046728 @default.
• W1967579647 cites W2112669742 @default.
• W1967579647 cites W2113096832 @default.
• W1967579647 cites W2115919618 @default.
• W1967579647 cites W2137447301 @default.
• W1967579647 cites W2152155070 @default.
• W1967579647 cites W2154164013 @default.
• W1967579647 doi "https://doi.org/10.1097/qai.0000000000000473" @default.
• W1967579647 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25501612" @default.
• W1967579647 hasPublicationYear "2015" @default.
• W1967579647 type Work @default.
• W1967579647 sameAs 1967579647 @default.
• W1967579647 citedByCount "11" @default.
• W1967579647 countsByYear W19675796472015 @default.
• W1967579647 countsByYear W19675796472016 @default.
• W1967579647 countsByYear W19675796472017 @default.
• W1967579647 countsByYear W19675796472018 @default.
• W1967579647 countsByYear W19675796472019 @default.
• W1967579647 countsByYear W19675796472020 @default.
• W1967579647 countsByYear W19675796472021 @default.
• W1967579647 countsByYear W19675796472022 @default.
• W1967579647 crossrefType "journal-article" @default.
• W1967579647 hasAuthorship W1967579647A5028609590 @default.
• W1967579647 hasAuthorship W1967579647A5031880803 @default.
• W1967579647 hasAuthorship W1967579647A5031998757 @default.
• W1967579647 hasAuthorship W1967579647A5033709878 @default.
• W1967579647 hasAuthorship W1967579647A5044293886 @default.
• W1967579647 hasAuthorship W1967579647A5044459845 @default.
• W1967579647 hasAuthorship W1967579647A5051817115 @default.
• W1967579647 hasAuthorship W1967579647A5055819465 @default.
• W1967579647 hasAuthorship W1967579647A5067750617 @default.
• W1967579647 hasAuthorship W1967579647A5075051424 @default.
• W1967579647 hasAuthorship W1967579647A5084027922 @default.
• W1967579647 hasBestOaLocation W19675796471 @default.
• W1967579647 hasConcept C104317684 @default.
• W1967579647 hasConcept C114851261 @default.
• W1967579647 hasConcept C126322002 @default.
• W1967579647 hasConcept C142462285 @default.
• W1967579647 hasConcept C156719811 @default.
• W1967579647 hasConcept C159047783 @default.
• W1967579647 hasConcept C203014093 @default.
• W1967579647 hasConcept C207103383 @default.
• W1967579647 hasConcept C2522874641 @default.
• W1967579647 hasConcept C2777351918 @default.
• W1967579647 hasConcept C2777869810 @default.
• W1967579647 hasConcept C2779130552 @default.
• W1967579647 hasConcept C2779889181 @default.
• W1967579647 hasConcept C2780216070 @default.
• W1967579647 hasConcept C2780593183 @default.
• W1967579647 hasConcept C2780727368 @default.
• W1967579647 hasConcept C2781413609 @default.
• W1967579647 hasConcept C2993143319 @default.
• W1967579647 hasConcept C3013748606 @default.
• W1967579647 hasConcept C44249647 @default.
• W1967579647 hasConcept C49105822 @default.
• W1967579647 hasConcept C54355233 @default.
• W1967579647 hasConcept C71924100 @default.
• W1967579647 hasConcept C86803240 @default.

• next