FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967594043> ?p ?o ?g. }

• W1967594043 endingPage "93" @default.
• W1967594043 startingPage "86" @default.
• W1967594043 abstract "In utero ethanol exposure impairs the development of several neurotransmitter systems, including the serotonergic system. However, at present the mechanism by which in utero ethanol exposure damages the developing brain is unknown. This research examined the possibility that ethanol directly impairs the development of serotonergic neurons. This hypothesis was assessed by examining the content of serotonin (5-HT), 5-HT uptake, and 5-HT immunopositive neurons in cultures of fetal rhombencephalic neurons that were exposed to ethanol for 4 days in vitro. In addition, the effects of in vitro ethanol exposure on protein and DNA content of cultured rhombencephalic neurons were determined. These studies demonstrated that a 4-day exposure of cultured rhombencephatic neurons to 50 to 300 mg ethanol/dl did not affect 5-HT content, 5-HT uptake, or the proportion of 5-HT immunopositive neurons. In addition, this ethanol exposure had no significant effect on protein or DNA content. Additional studies, using a 4-day exposure to 450 mg ethanol/dl also did not detect significant differences in 5-HT uptake or in protein or DNA content. The marked differences in the findings of the present in vitro and previous in vivo studies may be due to the fact that the ethanol exposure in vivo was longer than that in vitro, and included the period of early development of serotonergic neurons and their progenitors. Alternatively, the differences may be due to ethanol-associated alterations in maternal or fetal factors (e.g., hormones, amino acids, and growth factors) that are necessary for the normal development of the serotonergic system in vivo. Normal concentrations of such factors in the serum-containing media may have protected the cultured neurons from the damaging effects of ethanol." @default.
• W1967594043 created "2016-06-24" @default.
• W1967594043 creator A5007298207 @default.
• W1967594043 creator A5065679358 @default.
• W1967594043 date "1993-02-01" @default.
• W1967594043 modified "2023-10-18" @default.
• W1967594043 title "Effects of Ethanol on Cultured Fetal Serotonergic Neurons" @default.
• W1967594043 cites W1775749144 @default.
• W1967594043 cites W1906197854 @default.
• W1967594043 cites W1975277071 @default.
• W1967594043 cites W1977347112 @default.
• W1967594043 cites W1981282152 @default.
• W1967594043 cites W1981286824 @default.
• W1967594043 cites W1982479291 @default.
• W1967594043 cites W1984646640 @default.
• W1967594043 cites W1985057945 @default.
• W1967594043 cites W1987880044 @default.
• W1967594043 cites W1994351024 @default.
• W1967594043 cites W1997728817 @default.
• W1967594043 cites W1999180056 @default.
• W1967594043 cites W1999961136 @default.
• W1967594043 cites W2002058255 @default.
• W1967594043 cites W2003138967 @default.
• W1967594043 cites W2006838601 @default.
• W1967594043 cites W2016411315 @default.
• W1967594043 cites W2018526785 @default.
• W1967594043 cites W2020403787 @default.
• W1967594043 cites W2029724859 @default.
• W1967594043 cites W2032347195 @default.
• W1967594043 cites W2034408205 @default.
• W1967594043 cites W2037587096 @default.
• W1967594043 cites W2038174426 @default.
• W1967594043 cites W2050571228 @default.
• W1967594043 cites W2053898646 @default.
• W1967594043 cites W2054683121 @default.
• W1967594043 cites W2057612940 @default.
• W1967594043 cites W2061732252 @default.
• W1967594043 cites W2062927127 @default.
• W1967594043 cites W2066931434 @default.
• W1967594043 cites W2068535052 @default.
• W1967594043 cites W2068841903 @default.
• W1967594043 cites W2076646611 @default.
• W1967594043 cites W2078803647 @default.
• W1967594043 cites W2087548761 @default.
• W1967594043 cites W2095211180 @default.
• W1967594043 cites W2117514228 @default.
• W1967594043 cites W2117906839 @default.
• W1967594043 cites W2126477835 @default.
• W1967594043 cites W2153298256 @default.
• W1967594043 cites W2153588984 @default.
• W1967594043 cites W2274606944 @default.
• W1967594043 cites W2324207631 @default.
• W1967594043 cites W72684297 @default.
• W1967594043 doi "https://doi.org/10.1111/j.1530-0277.1993.tb00730.x" @default.
• W1967594043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8383927" @default.
• W1967594043 hasPublicationYear "1993" @default.
• W1967594043 type Work @default.
• W1967594043 sameAs 1967594043 @default.
• W1967594043 citedByCount "8" @default.
• W1967594043 countsByYear W19675940432016 @default.
• W1967594043 crossrefType "journal-article" @default.
• W1967594043 hasAuthorship W1967594043A5007298207 @default.
• W1967594043 hasAuthorship W1967594043A5065679358 @default.
• W1967594043 hasConcept C126322002 @default.
• W1967594043 hasConcept C134018914 @default.
• W1967594043 hasConcept C150903083 @default.
• W1967594043 hasConcept C170493617 @default.
• W1967594043 hasConcept C172680121 @default.
• W1967594043 hasConcept C185592680 @default.
• W1967594043 hasConcept C201614185 @default.
• W1967594043 hasConcept C202751555 @default.
• W1967594043 hasConcept C207001950 @default.
• W1967594043 hasConcept C2775864247 @default.
• W1967594043 hasConcept C2776219046 @default.
• W1967594043 hasConcept C2779234561 @default.
• W1967594043 hasConcept C2780161600 @default.
• W1967594043 hasConcept C37000724 @default.
• W1967594043 hasConcept C529278444 @default.
• W1967594043 hasConcept C54355233 @default.
• W1967594043 hasConcept C55493867 @default.
• W1967594043 hasConcept C71924100 @default.
• W1967594043 hasConcept C86803240 @default.
• W1967594043 hasConceptScore W1967594043C126322002 @default.
• W1967594043 hasConceptScore W1967594043C134018914 @default.
• W1967594043 hasConceptScore W1967594043C150903083 @default.
• W1967594043 hasConceptScore W1967594043C170493617 @default.
• W1967594043 hasConceptScore W1967594043C172680121 @default.
• W1967594043 hasConceptScore W1967594043C185592680 @default.
• W1967594043 hasConceptScore W1967594043C201614185 @default.
• W1967594043 hasConceptScore W1967594043C202751555 @default.
• W1967594043 hasConceptScore W1967594043C207001950 @default.
• W1967594043 hasConceptScore W1967594043C2775864247 @default.
• W1967594043 hasConceptScore W1967594043C2776219046 @default.
• W1967594043 hasConceptScore W1967594043C2779234561 @default.
• W1967594043 hasConceptScore W1967594043C2780161600 @default.
• W1967594043 hasConceptScore W1967594043C37000724 @default.
• W1967594043 hasConceptScore W1967594043C529278444 @default.
• W1967594043 hasConceptScore W1967594043C54355233 @default.

• next