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• W1967599572 abstract "Background In Down syndrome screening programmes, women with a previous affected pregnancy are assumed to have the same marker distribution as those without a family history. This assumption needs to be tested. Methods Information on previous aneuploidy pregnancies was routinely sought on the test request forms in three centres, Leeds, Romford and the Fetal Medicine Centre, London. For each woman with a previous aneuploidy (case), five unaffected pregnancies to women without a history were selected as controls. The markers tested included maternal serum free β-human chorionic gonadotrophin (hCG), pregnancy-associated plasma protein A (PAPP-A), α-fetoprotein, unconjugated estriol and ultrasound nuchal translucency thickness. Results There were 375 cases: 303 with previous Down syndrome, 63 with Edwards syndrome and 9 with Patau's syndrome. There was a statistically significant difference between cases and controls, in the distribution of free β-hCG and PAPP-A levels, adjusted for gestation. On average, free β-hCG was increased by 10% in a subsequent pregnancy after aneuploidy (p < 0.005, Wilcoxon rank sum test) and for PAPP-A the increase was 15% (p < 0.0001). No other marker was significantly different. Conclusion Risk calculation algorithms need to be modified to take account of the increased marker levels. Until data from sufficient affected pregnancies are available for study, it would be prudent to assume that the same increase as in unaffected pregnancies applies. Copyright © 2005 John Wiley & Sons, Ltd." @default.
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• W1967599572 date "2005-01-01" @default.
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• W1967599572 title "Down syndrome screening marker levels in women with a previous aneuploidy pregnancy" @default.
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• W1967599572 doi "https://doi.org/10.1002/pd.1082" @default.
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