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- W1967610367 abstract "Cytotoxic exposure of bone marrow and other non-hematopoietic organs containing self-renewing stem cell populations is associated with damage to the supportive microenvironment. Recent evidence indicates that radical oxygen species resulting from the initial oxidative stress persist for months after ionizing irradiation exposure of tissues including oral cavity, esophagus, lung and bone marrow. Antioxidant gene therapy using manganese superoxide dismutase plasmid liposomes has provided organ-specific radiation protection associated with delay or prevention of acute and late toxicity. Recent evidence has suggested that manganese superoxide dismutase transgene expression in cells of the organ microenvironment contributes significantly to the mechanism of protection. Incorporating this knowledge into designs of novel approaches for stem cell protection is addressed in the present review." @default.
- W1967610367 created "2016-06-24" @default.
- W1967610367 creator A5063266916 @default.
- W1967610367 date "2007-08-16" @default.
- W1967610367 modified "2023-09-26" @default.
- W1967610367 title "Gene therapy approaches for stem cell protection" @default.
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- W1967610367 doi "https://doi.org/10.1038/sj.gt.3303004" @default.
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