FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967612488> ?p ?o ?g. }

• W1967612488 endingPage "168" @default.
• W1967612488 startingPage "151" @default.
• W1967612488 abstract "Metastatic breast cancer is incurable but often responsive to treatment. There is little evidence-based consenus on when to use which treatments, in what combination and for how long. Systematic reviews were performed on 12 prospectively defined, clinically relevant research questions to support the development of evidence-based clinical practice guidelines. A comprehensive search of Medline from 1966 to 1996 identifed over 1800 controlled trials. Eligibility and data extraction were performed independently by two blinded reviewers. Trial results were summarised by ratios of median survivals (RMS) and P -values for survival curve comparisons with meta-analysis by weighted combination of these statistics. Sixty-five publications reporting 97 treatment comparisons were included. There was moderate evidence that more rather than fewer cycles of chemotherapy improved survival (RMS:1.23, P -0.01). The evidence did not support: higher rather than lower doses of chemotherapy (or of endocrine therapy); any one class of endocrine agent over all others; multiple endocrine agents over a single agent; or, combined chemotherapy and endocrine therapy over either single modality. Only six trials assessed quality of life revealing better quality of life with more rather than fewer cycles of chemotherapy and with standard rather than lower doses of chemotherapy. These systematic reviews reveal counterintuitive evidence useful to everyday practice, in particular that more rather than fewer cycles of chemotherapy lead to better quality of life and longer survival." @default.
• W1967612488 created "2016-06-24" @default.
• W1967612488 creator A5031309734 @default.
• W1967612488 creator A5043048253 @default.
• W1967612488 creator A5061757629 @default.
• W1967612488 creator A5084040956 @default.
• W1967612488 date "2000-06-01" @default.
• W1967612488 modified "2023-09-23" @default.
• W1967612488 title "Systematic reviews of chemotherapy and endocrine therapy in metastatic breast cancer" @default.
• W1967612488 cites W1527233101 @default.
• W1967612488 cites W1776991082 @default.
• W1967612488 cites W1836115940 @default.
• W1967612488 cites W1859111894 @default.
• W1967612488 cites W1872096120 @default.
• W1967612488 cites W1884665868 @default.
• W1967612488 cites W1893678663 @default.
• W1967612488 cites W1900639705 @default.
• W1967612488 cites W1911641538 @default.
• W1967612488 cites W1935850422 @default.
• W1967612488 cites W1943320567 @default.
• W1967612488 cites W1946018534 @default.
• W1967612488 cites W1967484801 @default.
• W1967612488 cites W1972656449 @default.
• W1967612488 cites W1973836728 @default.
• W1967612488 cites W1978054190 @default.
• W1967612488 cites W1984527604 @default.
• W1967612488 cites W1987684534 @default.
• W1967612488 cites W1993235281 @default.
• W1967612488 cites W1998710326 @default.
• W1967612488 cites W2010034069 @default.
• W1967612488 cites W2010537823 @default.
• W1967612488 cites W2012194655 @default.
• W1967612488 cites W2013657890 @default.
• W1967612488 cites W2014328262 @default.
• W1967612488 cites W2018667612 @default.
• W1967612488 cites W2020170892 @default.
• W1967612488 cites W2021915127 @default.
• W1967612488 cites W2033238186 @default.
• W1967612488 cites W2036338253 @default.
• W1967612488 cites W2039356896 @default.
• W1967612488 cites W2048672028 @default.
• W1967612488 cites W2049435590 @default.
• W1967612488 cites W2050662626 @default.
• W1967612488 cites W2052421758 @default.
• W1967612488 cites W2056760436 @default.
• W1967612488 cites W2057879841 @default.
• W1967612488 cites W2058306712 @default.
• W1967612488 cites W2062393754 @default.
• W1967612488 cites W2063989167 @default.
• W1967612488 cites W2069736881 @default.
• W1967612488 cites W2074030971 @default.
• W1967612488 cites W2075750518 @default.
• W1967612488 cites W2078978409 @default.
• W1967612488 cites W2083805278 @default.
• W1967612488 cites W2088773542 @default.
• W1967612488 cites W2093774212 @default.
• W1967612488 cites W2127714096 @default.
• W1967612488 cites W2135828743 @default.
• W1967612488 cites W2137792512 @default.
• W1967612488 cites W2151970467 @default.
• W1967612488 cites W2164380463 @default.
• W1967612488 cites W2164489340 @default.
• W1967612488 cites W2169073956 @default.
• W1967612488 cites W2176896925 @default.
• W1967612488 cites W2223030376 @default.
• W1967612488 cites W2225973205 @default.
• W1967612488 cites W2248572116 @default.
• W1967612488 cites W2253920138 @default.
• W1967612488 cites W2264660216 @default.
• W1967612488 cites W2268812590 @default.
• W1967612488 cites W2270235662 @default.
• W1967612488 cites W2289272461 @default.
• W1967612488 cites W2312623985 @default.
• W1967612488 cites W2339954912 @default.
• W1967612488 cites W2409909369 @default.
• W1967612488 cites W2415712440 @default.
• W1967612488 cites W4241240326 @default.
• W1967612488 cites W4243116045 @default.
• W1967612488 cites W4245415106 @default.
• W1967612488 doi "https://doi.org/10.1053/ctrv.1999.0161" @default.
• W1967612488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10814559" @default.
• W1967612488 hasPublicationYear "2000" @default.
• W1967612488 type Work @default.
• W1967612488 sameAs 1967612488 @default.
• W1967612488 citedByCount "197" @default.
• W1967612488 countsByYear W19676124882012 @default.
• W1967612488 countsByYear W19676124882013 @default.
• W1967612488 countsByYear W19676124882014 @default.
• W1967612488 countsByYear W19676124882015 @default.
• W1967612488 countsByYear W19676124882016 @default.
• W1967612488 countsByYear W19676124882017 @default.
• W1967612488 countsByYear W19676124882018 @default.
• W1967612488 countsByYear W19676124882019 @default.
• W1967612488 countsByYear W19676124882020 @default.
• W1967612488 countsByYear W19676124882021 @default.
• W1967612488 countsByYear W19676124882022 @default.
• W1967612488 countsByYear W19676124882023 @default.
• W1967612488 crossrefType "journal-article" @default.

• next