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• W1967629774 abstract "The effect of short-term cryopreservation on metabolic, functional, and survival characteristics of erythrocytes from patients with sickle cell disease was examined. Post-thaw hemolysis of glycerolized sickle (SS) erythrocytes was greater (mean 12.9%) than in hemoglobin-AA cells (mean 4.7%). Freeze preservation had no apparent effect on red cell morphology, percent irreversibly sickled cells, and fetal hemoglobin content. There were modest reductions in ATP and 2,3-diphosphoglycerate in thawed, washed sickle erythrocytes (12.7% and 29.7%, respectively). However, the autologous survival of 51Cr-labelled SS red cells was not shortened by cryopreservation. The safety and efficacy of autotransfusion of cryopreserved red cells in alloimmunized sickle cell disease patients with anemic episodes unrelated to sickling need to be determined." @default.
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• W1967629774 date "1981-05-01" @default.
• W1967629774 modified "2023-10-06" @default.
• W1967629774 title "Freeze preservation of sickle erythrocytes" @default.
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• W1967629774 doi "https://doi.org/10.1002/ajh.2830100309" @default.
• W1967629774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7246537" @default.
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