FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967655340> ?p ?o ?g. }

• W1967655340 endingPage "250" @default.
• W1967655340 startingPage "239" @default.
• W1967655340 abstract "Autoimmunity and tumor immunity evolved as two distinct arenas in immunological research. However, the identification of self-antigens as the major components of malignant cells may define a central role for autoimmunity in cancer control tuned by peripheral immunoregulatory mechanisms avoiding self-aggression. Emerging evidence documents a triple antagonistic role of interleukin-2 (IL-2) in vivo promoting survival, apoptosis, and the generation of regulatory T cells. We have found that IL-2 administration reduces the clinical course of experimental autoimmune encephalomyelitis and enhances immunoregulation in tumor-bearing mice. However, actively induced anti-IL-2 antibodies restore the response to nominal antigens in tumor-induced immunosuppressed host and induced therapeutic effect in transplantable and chemically induced tumors. It is suggested that IL-2 may contribute dynamically to the maintenance of natural immunological tolerance, preventing pathological autoimmunity, but may affect antitumor immunity. Cancer research has gained from autoimmunity understanding that tumor escape strategies include the natural mechanisms of immune tolerance and the ways to imbalance the peripheral regulatory mechanisms. Interestingly, therapeutic manipulations of immunoregulation have limited antitumor effects, although promoting collaterally infrequent autoimmune diseases. It may suggest that tumors may reinforce tolerance to protect themselves from the immune attack, a process that may involve dynamically various mechanisms including IL-2. Understanding this acquired experience from tumors may help utilize them to revert the immunopathology in autoimmune diseases." @default.
• W1967655340 created "2016-06-24" @default.
• W1967655340 creator A5030297062 @default.
• W1967655340 creator A5033721714 @default.
• W1967655340 creator A5065298283 @default.
• W1967655340 creator A5070534105 @default.
• W1967655340 date "2007-06-01" @default.
• W1967655340 modified "2023-10-01" @default.
• W1967655340 title "Interleukin-2 Mastering Regulation in Cancer and Autoimmunity" @default.
• W1967655340 cites W1483194800 @default.
• W1967655340 cites W1504124862 @default.
• W1967655340 cites W1515251449 @default.
• W1967655340 cites W1516581843 @default.
• W1967655340 cites W1585826109 @default.
• W1967655340 cites W1767246521 @default.
• W1967655340 cites W1921702206 @default.
• W1967655340 cites W1954238330 @default.
• W1967655340 cites W1964190957 @default.
• W1967655340 cites W1967550161 @default.
• W1967655340 cites W1967577151 @default.
• W1967655340 cites W1967884480 @default.
• W1967655340 cites W1969797237 @default.
• W1967655340 cites W1972886892 @default.
• W1967655340 cites W1973154834 @default.
• W1967655340 cites W1974620735 @default.
• W1967655340 cites W1982139065 @default.
• W1967655340 cites W1984666922 @default.
• W1967655340 cites W1985126564 @default.
• W1967655340 cites W1993149812 @default.
• W1967655340 cites W1996642272 @default.
• W1967655340 cites W2000208875 @default.
• W1967655340 cites W2001686438 @default.
• W1967655340 cites W2006136741 @default.
• W1967655340 cites W2007923854 @default.
• W1967655340 cites W2010462935 @default.
• W1967655340 cites W2017579442 @default.
• W1967655340 cites W2021741673 @default.
• W1967655340 cites W2036314272 @default.
• W1967655340 cites W2045108569 @default.
• W1967655340 cites W2053798662 @default.
• W1967655340 cites W2056603123 @default.
• W1967655340 cites W2074895307 @default.
• W1967655340 cites W2075433631 @default.
• W1967655340 cites W2075637497 @default.
• W1967655340 cites W2097074641 @default.
• W1967655340 cites W2103711360 @default.
• W1967655340 cites W2107629538 @default.
• W1967655340 cites W2109923158 @default.
• W1967655340 cites W2111457140 @default.
• W1967655340 cites W2114124794 @default.
• W1967655340 cites W2115131874 @default.
• W1967655340 cites W2116554142 @default.
• W1967655340 cites W2123809685 @default.
• W1967655340 cites W2126091327 @default.
• W1967655340 cites W2133329005 @default.
• W1967655340 cites W2135245523 @default.
• W1967655340 cites W2138163780 @default.
• W1967655340 cites W2145751474 @default.
• W1967655340 cites W2146600597 @default.
• W1967655340 cites W2148473794 @default.
• W1967655340 cites W2150678612 @default.
• W1967655340 cites W2151507811 @default.
• W1967655340 cites W2157822148 @default.
• W1967655340 cites W2158500407 @default.
• W1967655340 cites W2162819001 @default.
• W1967655340 cites W2164701887 @default.
• W1967655340 cites W2444336474 @default.
• W1967655340 cites W4211183651 @default.
• W1967655340 cites W4256189622 @default.
• W1967655340 cites W4313335094 @default.
• W1967655340 doi "https://doi.org/10.1196/annals.1381.026" @default.
• W1967655340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17804552" @default.
• W1967655340 hasPublicationYear "2007" @default.
• W1967655340 type Work @default.
• W1967655340 sameAs 1967655340 @default.
• W1967655340 citedByCount "8" @default.
• W1967655340 countsByYear W19676553402012 @default.
• W1967655340 countsByYear W19676553402013 @default.
• W1967655340 countsByYear W19676553402018 @default.
• W1967655340 countsByYear W19676553402021 @default.
• W1967655340 crossrefType "journal-article" @default.
• W1967655340 hasAuthorship W1967655340A5030297062 @default.
• W1967655340 hasAuthorship W1967655340A5033721714 @default.
• W1967655340 hasAuthorship W1967655340A5065298283 @default.
• W1967655340 hasAuthorship W1967655340A5070534105 @default.
• W1967655340 hasConcept C121608353 @default.
• W1967655340 hasConcept C147483822 @default.
• W1967655340 hasConcept C203014093 @default.
• W1967655340 hasConcept C2777016536 @default.
• W1967655340 hasConcept C2777701055 @default.
• W1967655340 hasConcept C2777702733 @default.
• W1967655340 hasConcept C2778486448 @default.
• W1967655340 hasConcept C2780130043 @default.
• W1967655340 hasConcept C502942594 @default.
• W1967655340 hasConcept C54355233 @default.
• W1967655340 hasConcept C86803240 @default.
• W1967655340 hasConcept C8891405 @default.
• W1967655340 hasConceptScore W1967655340C121608353 @default.

• next